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The Sleep/Wake Cycl...
The Sleep/Wake Cycle is Directly Modulated by Changes in Energy Balance
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Collet, T. H. (author)
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van der Klaauw, A. A. (author)
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Henning, E. (author)
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Keogh, J. M. (author)
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Suddaby, D. (author)
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Dachi, S. V. (author)
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Dunbar, S. (author)
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Kelway, S. (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Farooqi, I. S. (author)
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Schmid, S. M. (author)
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(creator_code:org_t)
- Oxford University Press (OUP), 2016
- 2016
- English.
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In: Sleep. - : Oxford University Press (OUP). - 0161-8105 .- 1550-9109. ; 39:9, s. 1691-1700
- Related links:
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https://academic.oup...
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https://gup.ub.gu.se...
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https://doi.org/10.5...
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Abstract
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- Study Objectives: The rise in obesity has been paralleled by a decline in sleep duration in epidemiological studies. However, the potential mechanisms linking energy balance and the sleep/wake cycle are not well understood. We aimed to examine the effects of manipulating energy balance on the sleep/wake cycle. Methods: Twelve healthy normal weight men were housed in a clinical research facility and studied at three time points: baseline, after energy balance was disrupted by 2 days of caloric restriction to 10% of energy requirements, and after energy balance was restored by 2 days of ad libitum/free feeding. Sleep architecture, duration of sleep stages, and sleep-associated respiratory parameters were measured by polysomnography. Results: Two days of caloric restriction significantly increased the duration of deep (stage 4) sleep (16.8% to 21.7% of total sleep time; P = 0.03); an effect which was entirely reversed upon free feeding (P = 0.01). Although the apnea-hypopnea index stayed within the reference range (< 5 events per hour), it decreased significantly from caloric restriction to free feeding (P = 0.03). Caloric restriction was associated with a marked fall in leptin (P < 0.001) and insulin levels (P = 0.002). The fall in orexin levels from baseline to caloric restriction correlated positively with duration of stage 4 sleep (Spearman rho = 0.83, P = 0.01) and negatively with the number of awakenings in caloric restriction (Spearman rho = -0.79, P = 0.01). Conclusions: We demonstrate that changes in energy homeostasis directly and reversibly impact on the sleep/wake cycle. These findings provide a mechanistic framework for investigating the association between sleep duration and obesity risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- sleep
- caloric restriction
- leptin
- orexin
- slow-wave sleep
- daytime sleepiness
- ghrelin levels
- leptin levels
- gh
- secretion
- obesity
- duration
- hormone
- weight
- humans
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sleep
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- By the author/editor
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Collet, T. H.
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van der Klaauw, ...
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Henning, E.
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Keogh, J. M.
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Suddaby, D.
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Dachi, S. V.
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show more...
-
Dunbar, S.
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Kelway, S.
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Dickson, Suzanne ...
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Farooqi, I. S.
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Schmid, S. M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Sleep
- By the university
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University of Gothenburg