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Respiratory hyperse...
Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA(2)LEN) survey
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- Makowska, J. S. (author)
- Med Univ Lodz, Dept Rheumatol, PL-90131 Lodz, Poland.
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- Burney, P. (author)
- Imperial Coll, Dept Resp Epidemiol & Publ Hlth, London, England.
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- Jarvis, D. (author)
- Imperial Coll, Dept Resp Epidemiol & Publ Hlth, London, England.
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- Keil, T. (author)
- Charite, Inst Social Med, Epidemiol & Hlth Econ, Berlin, Germany.
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- Tomassen, P. (author)
- Univ Ghent, Dept Otorhinolaryngol & Logopaedic Audiol Sci, Upper Airways Res Lab, Ghent, Belgium.
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- Bislimovska, J. (author)
- Univ Sts Cyril & Methodius Skopje, Inst Occupat Hlth R Macedonia, Skopje, Macedonia.
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- Brozek, G. (author)
- Med Univ Silesia, Fac Med, Dept Epidemiol, Katowice, Poland.
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- Bachert, C. (author)
- Karolinska Institutet
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- Baelum, J. (author)
- Odense Univ Hosp, Dept Occupat & Environm Med, Odense, Denmark.
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- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
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- Bousquet, J. (author)
- Univ Montpellier, Dept Resp Med, Montpellier, France.
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Bousquet, P. J. (author)
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- Kai-Hakon, C. (author)
- Oslo Univ Hosp, Rikshospitalet, Oslo, Norway.
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- Dahlen, S. E. (author)
- Karolinska Institutet
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- Dahlen, B. (author)
- Karolinska Institutet
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- Fokkens, W. J. (author)
- Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, Amsterdam, Netherlands.
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- Forsberg, Bertil (author)
- Umeå universitet,Yrkes- och miljömedicin,Arcum
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- Gjomarkaj, M. (author)
- Inst Biomed & Mol Immunol, Dept Resp Med, Palermo, Italy.
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- Howarth, P. (author)
- Univ Southampton, Dept Resp Cell & Mol Biol, Southampton, Hants, England.
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Salagean, E. (author)
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Janson, C. (author)
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- Kasper, L. (author)
- Jagiellonian Univ Krakow, Dept Internal Med, Krakow, Poland.
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- Kraemer, U. (author)
- Heinrich Heine Univ, Environm Hlth Res Inst, Dusseldorf, Germany.;Tech Univ Munich, Dept Dermatol & Allergy, Munich, Germany.
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- Louiro, C. (author)
- Univ Hosp Coimbra, Dept Immunol & Allergol, Coimbra, Portugal.
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- Lundbäck, Bo, 1948 (author)
- Gothenburg University,Göteborgs universitet,Krefting Research Centre,Univ Gothenburg, Krefting Res Ctr, Gothenburg, Sweden.
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- Minov, J. (author)
- Univ Sts Cyril & Methodius Skopje, Inst Occupat Hlth R Macedonia, Skopje, Macedonia.
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- Nizankowska-Mogilnicka, E. (author)
- Jagiellonian Univ Krakow, Dept Internal Med, Krakow, Poland.
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- Papadopoulos, N. (author)
- Univ Athens, Allergy Dept Paediat Clin 2, Athens, Greece.
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- Sakellariou, A. G. (author)
- Univ Athens, Allergy Dept Paediat Clin 2, Athens, Greece.
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- Todo-Bom, A. (author)
- Univ Hosp Coimbra, Dept Immunol & Allergol, Coimbra, Portugal.
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- Toskala, E. (author)
- Helsinki Univ Hosp, Finnish Inst Occupat Hlth, Dept Otorhinolaryngol, Helsinki, Finland.;Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA USA.
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- Zejda, J. E. (author)
- Med Univ Silesia, Fac Med, Dept Epidemiol, Katowice, Poland.
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- Zuberbier, T. (author)
- Charite, Dept Dermatol & Allergy, Berlin, Germany.
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- Kowalski, M. L. (author)
- Med Univ Lodz, Dept Immunol Rheumatol & Allergy, Lodz, Poland.
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Med Univ Lodz, Dept Rheumatol, PL-90131 Lodz, Poland Imperial Coll, Dept Resp Epidemiol & Publ Hlth, London, England. (creator_code:org_t)
- 2016-07-11
- 2016
- English.
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In: Allergy. - : Wiley. - 0105-4538 .- 1398-9995. ; 71:11, s. 1603-1611
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Abstract
Subject headings
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- BackgroundNonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders. MethodsThe GA(2)LEN survey was conducted in 22 centers in 15 European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled. Questionnaires including questions about age, gender, presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking status, and history of NSAID-induced hypersensitivity reactions were sent to participants by mail. Totally, 62 737 participants completed the questionnaires. ResultsThe mean prevalence of NSAID-induced dyspnea was 1.9% and was highest in the three Polish centers [Katowice (4.9%), Krakow (4.8%), and Lodz (4.4%)] and lowest in Skopje, (0.9%), Amsterdam (1.1%), and Umea (1.2%). In multivariate analysis, the prevalence of respiratory reactions to NSAIDs was higher in participants with chronic rhinosinusitis symptoms (Odds Ratio 2.12; 95%CI 1.78-2.74), asthma symptoms in last 12 months (2.7; 2.18-3.35), hospitalization due to asthma (1.53; 1.22-1.99), and adults vs children (1.53; 1.24-1.89), but was not associated with allergic rhinitis. ConclusionOur study documented significant variation between European countries in the prevalence of NSAID-induced respiratory hypersensitivity reactions, and association with chronic airway diseases, but also with environmental factors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- drug allergy
- epidemiology
- GA2LEN
- NSAIDs hypersensitivity
- NONSTEROIDAL ANTIINFLAMMATORY DRUGS
- ASPIRIN-INTOLERANT ASTHMA
- QUESTIONNAIRE SURVEY
- PROVOCATION TESTS
- NASAL POLYPOSIS
- NATURAL-HISTORY
- PREVALENCE
- POPULATION
- DISEASE
- CLASSIFICATION
- drug allergy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Allergy
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- By the author/editor
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Makowska, J. S.
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Burney, P.
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Jarvis, D.
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Keil, T.
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Tomassen, P.
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Bislimovska, J.
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show more...
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Brozek, G.
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Bachert, C.
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Baelum, J.
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Janson, Christer
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Bousquet, J.
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Bousquet, P. J.
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Kai-Hakon, C.
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Dahlen, S. E.
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Dahlen, B.
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Fokkens, W. J.
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Forsberg, Bertil
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Gjomarkaj, M.
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Howarth, P.
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Salagean, E.
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Janson, C.
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Kasper, L.
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Kraemer, U.
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Louiro, C.
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Lundbäck, Bo, 19 ...
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Minov, J.
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Nizankowska-Mogi ...
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Papadopoulos, N.
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Sakellariou, A. ...
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Todo-Bom, A.
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Toskala, E.
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Zejda, J. E.
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Zuberbier, T.
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Kowalski, M. L.
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Allergy
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University of Gothenburg
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Uppsala University
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Umeå University
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Karolinska Institutet