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Emergence and sprea...
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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American Association for the Advancement of Science (AAAS),2016
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/245839
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https://gup.ub.gu.se/publication/245839URI
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https://doi.org/10.1126/science.aaf8156DOI
Supplementary language notes
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Grogono, D. M.
(author)
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Rodriguez-Rincon, D.
(author)
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Everall, I.
(author)
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Brown, K. P.
(author)
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Moreno, P.
(author)
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Verma, D.
(author)
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Hill, E.
(author)
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Drijkoningen, J.
(author)
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Gilligan, P.
(author)
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Esther, C. R.
(author)
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Noone, P. G.
(author)
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Giddings, O.
(author)
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Bell, S. C.
(author)
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Thomson, R.
(author)
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Wainwright, C. E.
(author)
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Coulter, C.
(author)
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Pandey, S.
(author)
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Wood, M. E.
(author)
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Stockwell, R. E.
(author)
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Ramsay, K. A.
(author)
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Sherrard, L. J.
(author)
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Kidd, T. J.
(author)
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Jabbour, N.
(author)
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Johnson, G. R.
(author)
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Knibbs, L. D.
(author)
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Morawska, L.
(author)
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Sly, P. D.
(author)
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Jones, A.
(author)
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Bilton, D.
(author)
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Laurenson, I.
(author)
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Ruddy, M.
(author)
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Bourke, S.
(author)
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Bowler, Icjw
(author)
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Chapman, S. J.
(author)
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Clayton, A.
(author)
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Cullen, M.
(author)
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Dempsey, O.
(author)
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Denton, M.
(author)
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Desai, M.
(author)
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Drew, R. J.
(author)
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Edenborough, F.
(author)
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Evans, J.
(author)
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Folb, J.
(author)
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Daniels, T.
(author)
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Humphrey, H.
(author)
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Isalska, B.
(author)
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Jensen-Fangel, S.
(author)
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Jönsson, Bodil,1959Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine(Swepub:gu)xjobod
(author)
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Jones, A. M.
(author)
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Katzenstein, T. L.
(author)
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Lillebaek, T.
(author)
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MacGregor, G.
(author)
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Mayell, S.
(author)
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Millar, M.
(author)
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Modha, D.
(author)
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Nash, E. F.
(author)
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O'Brien, C.
(author)
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O'Brien, D.
(author)
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Ohri, C.
(author)
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Pao, C. S.
(author)
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Peckham, D.
(author)
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Perrin, F.
(author)
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Perry, A.
(author)
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Pressler, T.
(author)
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Prtak, L.
(author)
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Qvist, T.
(author)
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Robb, A.
(author)
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Rodgers, H.
(author)
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Schaffer, K.
(author)
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Shafi, N.
(author)
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van Ingen, J.
(author)
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Walshaw, M.
(author)
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Watson, D.
(author)
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West, N.
(author)
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Whitehouse, J.
(author)
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Haworth, C. S.
(author)
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Harris, S. R.
(author)
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Ordway, D.
(author)
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Parkhill, J.
(author)
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Floto, R. A.
(author)
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Göteborgs universitetInstitutionen för biomedicin, avdelningen för infektionssjukdomar
(creator_code:org_t)
Related titles
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In:Science: American Association for the Advancement of Science (AAAS)354:6313, s. 751-7570036-80751095-9203
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To the university's database
- By the author/editor
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Bryant, J. M.
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Grogono, D. M.
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Rodriguez-Rincon ...
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Everall, I.
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Brown, K. P.
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Moreno, P.
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show more...
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Verma, D.
-
Hill, E.
-
Drijkoningen, J.
-
Gilligan, P.
-
Esther, C. R.
-
Noone, P. G.
-
Giddings, O.
-
Bell, S. C.
-
Thomson, R.
-
Wainwright, C. E ...
-
Coulter, C.
-
Pandey, S.
-
Wood, M. E.
-
Stockwell, R. E.
-
Ramsay, K. A.
-
Sherrard, L. J.
-
Kidd, T. J.
-
Jabbour, N.
-
Johnson, G. R.
-
Knibbs, L. D.
-
Morawska, L.
-
Sly, P. D.
-
Jones, A.
-
Bilton, D.
-
Laurenson, I.
-
Ruddy, M.
-
Bourke, S.
-
Bowler, Icjw
-
Chapman, S. J.
-
Clayton, A.
-
Cullen, M.
-
Dempsey, O.
-
Denton, M.
-
Desai, M.
-
Drew, R. J.
-
Edenborough, F.
-
Evans, J.
-
Folb, J.
-
Daniels, T.
-
Humphrey, H.
-
Isalska, B.
-
Jensen-Fangel, S ...
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Jönsson, Bodil, ...
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Jones, A. M.
-
Katzenstein, T. ...
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Lillebaek, T.
-
MacGregor, G.
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Mayell, S.
-
Millar, M.
-
Modha, D.
-
Nash, E. F.
-
O'Brien, C.
-
O'Brien, D.
-
Ohri, C.
-
Pao, C. S.
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Peckham, D.
-
Perrin, F.
-
Perry, A.
-
Pressler, T.
-
Prtak, L.
-
Qvist, T.
-
Robb, A.
-
Rodgers, H.
-
Schaffer, K.
-
Shafi, N.
-
van Ingen, J.
-
Walshaw, M.
-
Watson, D.
-
West, N.
-
Whitehouse, J.
-
Haworth, C. S.
-
Harris, S. R.
-
Ordway, D.
-
Parkhill, J.
-
Floto, R. A.
-
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Science
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University of Gothenburg