Physiology, pathophysiology and therapeutic implications of enteroendocrine control of food intake

Introduction: With the increasing prevalence of obesity and its associated comorbidities, strides to improve treatment strategies have enhanced our understanding of the function of the gut in the regulation of food intake. The most successful intervention for obesity to date, bariatric surgery effectively manipulates enteroendocrine physiology to enhance satiety and reduce hunger. Areas covered: In the present article, we provide a detailed overview of the physiology of enteroendocrine control of food intake, and discuss its pathophysiologic correlates and therapeutic implications in both obesity and gastrointestinal disease. Expert commentary: Ongoing research in the field of nutrient sensing by L-cells, as well as understanding the role of the microbiome and bile acid signaling may facilitate the development of novel strategies to combat the rising population health threat associated with obesity. Further refinement of post-prandial satiety gut hormone based therapies, including the development of chimeric peptides exploiting the pleiotropic nature of the gut hormone response, and identification of novel methods of delivery may hold the key to optimization of therapeutic modulation of gut hormone physiology in obesity.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Gut hormones
obesity
appetite
hunger
satiety
glucagon-like peptide 1
GLP-1
ghrelin
peptide YY
PYY
oxyntomodulin
OXM
bariatric surgery
body weight
gastric bypass
RYGB
esophagectomy
gastrectomy
malnutrition
weight loss
anorexia
surger
glucagon-like peptide-1
y gastric bypass
laparoscopic sleeve
gastrectomy
short-bowel syndrome
high-fat diet
esophageal
cancer-surgery
morbidly obese subjects
agouti-related protein
dependent insulinotropic polypeptide
intestinal glucose-metabolism
Endocrinology & Metabolism

Reynolds, J. V. (author)
le Roux, Carel WGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xleroc (author)
Docherty, Neil G.Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education(Swepub:gu)xdocme (author)
Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning (creator_code:org_t)

In:Expert Review of Endocrinology & Metabolism: Informa UK Limited11:6, s. 475-4991744-66511744-8417

By the author/editor: Elliott, J. A.; Reynolds, J. V.; le Roux, Carel W; Docherty, Neil G ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

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