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  • O'Bryant, Sid E (author)

Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-11-18
  • Wiley,2016

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/246409
  • https://gup.ub.gu.se/publication/246409URI
  • https://doi.org/10.1016/j.jalz.2016.09.014DOI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The last decade has seen a substantial increase in research focused on the identification of blood-based biomarkers that have utility in Alzheimer's disease (AD). Blood-based biomarkers have significant advantages of being time- and cost-efficient as well as reduced invasiveness and increased patient acceptance. Despite these advantages and increased research efforts, the field has been hampered by lack of reproducibility and an unclear path for moving basic discovery toward clinical utilization. Here we reviewed the recent literature on blood-based biomarkers in AD to provide a current state of the art. In addition, a collaborative model is proposed that leverages academic and industry strengths to facilitate the field in moving past discovery only work and toward clinical use. Key resources are provided. This new public-private partnership model is intended to circumvent the traditional handoff model and provide a clear and useful paradigm for the advancement of biomarker science in AD and other neurodegenerative diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mielke, Michelle M (author)
  • Rissman, Robert A (author)
  • Lista, Simone (author)
  • Vanderstichele, Hugo (author)
  • Zetterberg, Henrik,1973Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry(Swepub:gu)xzethe (author)
  • Lewczuk, Piotr (author)
  • Posner, Holly (author)
  • Hall, James (author)
  • Johnson, Leigh (author)
  • Fong, Yiu-Lian (author)
  • Luthman, Johan (author)
  • Jeromin, Andreas (author)
  • Batrla-Utermann, Richard (author)
  • Villarreal, Alcibiades (author)
  • Britton, Gabrielle (author)
  • Snyder, Peter J (author)
  • Henriksen, Kim (author)
  • Grammas, Paula (author)
  • Gupta, Veer (author)
  • Martins, Ralph (author)
  • Hampel, Harald (author)
  • Göteborgs universitetInstitutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (creator_code:org_t)

Related titles

  • In:Alzheimer's & dementia : the journal of the Alzheimer's Association: Wiley13:1, s. 45-581552-5279
  • In:Alzheimer's & Dementia: Wiley13:1, s. 45-581552-5260

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