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Hypoxia reinforces ...
Hypoxia reinforces laryngeal reflex bradycardia in infants.
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- Wennergren, Göran, 1947 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för pediatrik,Department of pediatrics
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Hertzberg, T (author)
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Milerad, J (author)
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- Bjure, Jan (author)
- Gothenburg University,Göteborgs universitet,Institutionen för pediatrik,Department of pediatrics
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Lagercrantz, H (author)
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(creator_code:org_t)
- 1989
- 1989
- English.
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In: Acta paediatrica Scandinavica. - 0001-656X. ; 78:1, s. 11-7
- Related links:
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Abstract
Subject headings
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- The laryngeal chemoreflex involves bradycardia, apnea, swallowing and peripheral vasoconstriction. This reflex was studied in twelve infants, aged 5 days-28 weeks, who had sustained an apparent life-threatening event or were siblings of infants who had died of the sudden infant death syndrome. The bradycardic and apneic components of the reflex were found to be significantly, and sometimes powerfully, reinforced when elicited by pharyngeal water instillation during acute, mild hypoxia (transcutaneous PO2 4.6-8.3 kPa). Apnea duration during normoxia was 0.7-15 sec, and during hypoxia 2-30 sec. Heart rate change ranged from +26% to -21% during normoxia, as compared with -4% to -63% during hypoxia. The percentage change in heart rate was found to inversely correlate with the transcutaneous PO2-level prevailing when the reflex was elicited. The conclusion is that there is a significant reinforcement of the cardiorespiratory adjustments when the laryngeal reflex is activated during simultaneous excitation of the peripheral arterial chemoreceptors. One infant, showing a particularly strong increase of the cardiorespiratory response to laryngeal receptor stimulation during hypoxia, later died of sudden infant death syndrome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Keyword
- Blood Gas Monitoring
- Transcutaneous
- Chemoreceptor Cells
- physiology
- Heart Rate
- Humans
- Hypoxia
- physiopathology
- Infant
- Infant
- Newborn
- physiology
- Laryngeal Nerves
- physiology
- physiopathology
- Larynx
- physiology
- physiopathology
- Reflex
- physiology
- Respiration
- Risk Factors
- Sudden Infant Death
- physiopathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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