Sökning: onr:"swepub:oai:gup.ub.gu.se/248366" >
Women with Premenst...
-
Eriksson, Olle,1954-Uppsala universitet,Obstetrik & gynekologi,Gynekologisk endokrinologi,University of Uppsala Hospital, Sweden
(författare)
Women with Premenstrual Dysphoria Lack the Seemingly Normal Premenstrual Right-Sided Relative Dominance of 5-HTP-Derived Serotonergic Activity in the Dorsolateral Prefrontal Cortices - A Possible Cause of Disabling Mood Symptoms.
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
-
2016-09-12
-
Public Library of Science (PLoS),2016
Nummerbeteckningar
-
LIBRIS-ID:oai:gup.ub.gu.se/248366
-
https://gup.ub.gu.se/publication/248366URI
-
https://doi.org/10.1371/journal.pone.0159538DOI
-
https://res.slu.se/id/publ/78504URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-311612URI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-133400URI
Kompletterande språkuppgifter
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Funding Agencies|PET Foundation of the County of Uppsala; Amersham PET Fund; Swedish Medical Society; Soderstrom Konigska Foundation; Swedish Society for Medical Research; Family Planning Foundation of Uppsala University Hospital; Medical Faculty of the University of Uppsala
-
To investigate potential quantitative and qualitative differences in brain serotonergic activity between women with Premenstrual Dysphoria (PMD) and asymptomatic controls.Serotonin-augmenting drugs alleviate premenstrual mood symptoms in the majority of women with PMD while serotonin-depleting diets worsen PMD symptoms, both indicating intrinsic differences in brain serotonergic activity in women with PMD compared to asymptomatic women.Positron-emission tomography with the immediate precursor of serotonin, 5-hydroxytryptophan (5-HTP), radiolabelled by 11C in the beta-3 position, was performed in the follicular and luteal phases for 12 women with PMD and 8 control women. Brain radioactivity-a proxy for serotonin precursor uptake and synthesis-was measured in 9 regions of interest (ROIs): the right and left sides of the medial prefrontal cortex, dorsolateral prefrontal cortex, putamen and caudate nucleus, and the single "whole brain".There were no significant quantitative differences in brain 5-HTP-derived activity between the groups in either of the menstrual phases for any of the 9 ROIs. However, multivariate analysis revealed a significant quantitative and qualitative difference between the groups. Asymptomatic control women showed a premenstrual right sided relative increase in dorsolateral prefrontal cortex 5-HTP derived activity, whereas PMD women displayed the opposite (p = 0.0001). Menstrual phase changes in this asymmetry (premenstrual-follicular) correlated with changes in self ratings of 'irritability' for the entire group (rs = -0.595, p = 0.006). The PMD group showed a strong inverse correlation between phase changes (premenstrual-follicular) in plasma levels of estradiol and phase changes in the laterality (dx/sin) of radiotracer activity in the dorsolateral prefrontal ROI (rs = -0.635; 0.027). The control group showed no such correlation.Absence of increased premenstrual right-sided relative 5-HTP-derived activity of the dorsolateral prefrontal cortices was found to strongly correlate to premenstrual irritability. A causal relationship here seems plausible, and the findings give further support to an underlying frontal brain disturbance in hormonally influenced serotonergic activity in women with PMD. Because of the small number of subjects in the study, these results should be considered preliminary, requiring verification in larger studies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Wall, AndersUppsala universitet,Radiologi,University of Uppsala Hospital, Sweden(Swepub:uu)andewall
(författare)
-
Olsson, UlfSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för energi och teknik,Department of Energy and Technology,Swedish Univ Agr Sci, Unit Appl Stat & Math, Uppsala, Sweden.,Swedish University of Agriculture Science, Sweden(Swepub:slu)51184
(författare)
-
Marteinsdottir, InaLinköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken(Swepub:liu)inama76
(författare)
-
Holstad, MariaUniv Uppsala Hosp, Dept Neurosci, Psychiat Unit, Uppsala, Sweden.,University of Uppsala Hospital, Sweden
(författare)
-
Ågren, Hans,1945Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Univ Gothenburg, Inst Neurosci & Physiol, Gothenburg, Sweden.,University of Gothenburg, Sweden(Swepub:gu)xagrha
(författare)
-
Hartvig, PerUniv Copenhagen, Dept Drug Design & Pharmacol, Copenhagen, Denmark.,University of Copenhagen, Denmark
(författare)
-
Långström, BengtUppsala universitet,Organisk kemi,Uppsala University, Sweden(Swepub:uu)benglang
(författare)
-
Naessén, Tord,1951-Uppsala universitet,Obstetrik & gynekologi,Gynekologisk endokrinologi/Naessén,University of Uppsala Hospital, Sweden(Swepub:uu)tordnaes
(författare)
-
Uppsala universitetObstetrik & gynekologi
(creator_code:org_t)
-
Sveriges lantbruksuniversitet
Sammanhörande titlar
-
Ingår i:PloS one: Public Library of Science (PLoS)11:91932-6203
Internetlänk
Hitta via bibliotek
-
PloS one
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Eriksson, Olle, ...
-
Wall, Anders
-
Olsson, Ulf
-
Marteinsdottir, ...
-
Holstad, Maria
-
Ågren, Hans, 194 ...
-
visa fler...
-
Hartvig, Per
-
Långström, Bengt
-
Naessén, Tord, 1 ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Neurovetenskaper
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
- Artiklar i publikationen
-
PloS one
- Av lärosätet
-
Göteborgs universitet
-
Sveriges Lantbruksuniversitet
-
Uppsala universitet
-
Linköpings universitet