Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

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Fältnamn	Indikatorer	Metadata
000		07649naa a2201381 4500
001		oai:gup.ub.gu.se/248530
003		SwePub
008		240528s2016 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/2485302 URI
024	7	a https://doi.org/10.1001/jama.2016.19752 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Tyrrell, Jessica4 aut
245	1 0	a Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.
264	1	b American Medical Association (AMA),c 2016
520		a Neonates born to overweight or obese women are larger and at higher risk of birth complications. Many maternal obesity-related traits are observationally associated with birth weight, but the causal nature of these associations is uncertain.To test for genetic evidence of causal associations of maternal body mass index (BMI) and related traits with birth weight.Mendelian randomization to test whether maternal BMI and obesity-related traits are potentially causally related to offspring birth weight. Data from 30,487 women in 18 studies were analyzed. Participants were of European ancestry from population- or community-based studies in Europe, North America, or Australia and were part of the Early Growth Genetics Consortium. Live, term, singleton offspring born between 1929 and 2013 were included.Genetic scores for BMI, fasting glucose level, type 2 diabetes, systolic blood pressure (SBP), triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, vitamin D status, and adiponectin level.Offspring birth weight from 18 studies.Among the 30,487 newborns the mean birth weight in the various cohorts ranged from 3325 g to 3679 g. The maternal genetic score for BMI was associated with a 2-g (95% CI, 0 to 3 g) higher offspring birth weight per maternal BMI-raising allele (P=.008). The maternal genetic scores for fasting glucose and SBP were also associated with birth weight with effect sizes of 8 g (95% CI, 6 to 10 g) per glucose-raising allele (P=7×10(-14)) and -4 g (95% CI, -6 to -2 g) per SBP-raising allele (P=1×10(-5)), respectively. A 1-SD (≈4 points) genetically higher maternal BMI was associated with a 55-g higher offspring birth weight (95% CI, 17 to 93 g). A 1-SD (≈7.2 mg/dL) genetically higher maternal fasting glucose concentration was associated with 114-g higher offspring birth weight (95% CI, 80 to 147 g). However, a 1-SD (≈10 mm Hg) genetically higher maternal SBP was associated with a 208-g lower offspring birth weight (95% CI, -394 to -21 g). For BMI and fasting glucose, genetic associations were consistent with the observational associations, but for systolic blood pressure, the genetic and observational associations were in opposite directions.In this mendelian randomization study, genetically elevated maternal BMI and blood glucose levels were potentially causally associated with higher offspring birth weight, whereas genetically elevated maternal SBP was potentially causally related to lower birth weight. If replicated, these findings may have implications for counseling and managing pregnancies to avoid adverse weight-related birth outcomes.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
653		a Adult
653		a Birth Weight
653		a genetics
653		a Blood Glucose
653		a genetics
653		a Blood Pressure
653		a genetics
653		a Body Mass Index
653		a Diabetes Mellitus
653		a Type 2
653		a genetics
653		a European Continental Ancestry Group
653		a Fasting
653		a blood
653		a Female
653		a Genotype
653		a Humans
653		a Infant
653		a Newborn
653		a Mendelian Randomization Analysis
653		a Obesity
653		a blood
653		a ethnology
653		a genetics
653		a Polymorphism
653		a Single Nucleotide
653		a Pregnancy
653		a Triglycerides
653		a genetics
700	1	a Richmond, Rebecca C4 aut
700	1	a Palmer, Tom M4 aut
700	1	a Feenstra, Bjarke4 aut
700	1	a Rangarajan, Janani4 aut
700	1	a Metrustry, Sarah4 aut
700	1	a Cavadino, Alana4 aut
700	1	a Paternoster, Lavinia4 aut
700	1	a Armstrong, Loren L4 aut
700	1	a De Silva, N Maneka G4 aut
700	1	a Wood, Andrew R4 aut
700	1	a Horikoshi, Momoko4 aut
700	1	a Geller, Frank4 aut
700	1	a Myhre, Ronny4 aut
700	1	a Bradfield, Jonathan P4 aut
700	1	a Kreiner-Møller, Eskil4 aut
700	1	a Huikari, Ville4 aut
700	1	a Painter, Jodie N4 aut
700	1	a Hottenga, Jouke-Jan4 aut
700	1	a Allard, Catherine4 aut
700	1	a Berry, Diane J4 aut
700	1	a Bouchard, Luigi4 aut
700	1	a Das, Shikta4 aut
700	1	a Evans, David M4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Hayes, M Geoffrey4 aut
700	1	a Heikkinen, Jani4 aut
700	1	a Hofman, Albert4 aut
700	1	a Knight, Bridget4 aut
700	1	a Lind, Penelope A4 aut
700	1	a McCarthy, Mark I4 aut
700	1	a McMahon, George4 aut
700	1	a Medland, Sarah E4 aut
700	1	a Melbye, Mads4 aut
700	1	a Morris, Andrew P4 aut
700	1	a Nodzenski, Michael4 aut
700	1	a Reichetzeder, Christoph4 aut
700	1	a Ring, Susan M4 aut
700	1	a Sebert, Sylvain4 aut
700	1	a Sengpiel, Verena,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xsenve
700	1	a Sørensen, Thorkild I A4 aut
700	1	a Willemsen, Gonneke4 aut
700	1	a de Geus, Eco J C4 aut
700	1	a Martin, Nicholas G4 aut
700	1	a Spector, Tim D4 aut
700	1	a Power, Christine4 aut
700	1	a Järvelin, Marjo-Riitta4 aut
700	1	a Bisgaard, Hans4 aut
700	1	a Grant, Struan F A4 aut
700	1	a Nohr, Ellen A4 aut
700	1	a Jaddoe, Vincent W4 aut
700	1	a Jacobsson, Bo,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology4 aut0 (Swepub:gu)xjacbo
700	1	a Murray, Jeffrey C4 aut
700	1	a Hocher, Berthold4 aut
700	1	a Hattersley, Andrew T4 aut
700	1	a Scholtens, Denise M4 aut
700	1	a Davey Smith, George4 aut
700	1	a Hivert, Marie-France4 aut
700	1	a Felix, Janine F4 aut
700	1	a Hyppönen, Elina4 aut
700	1	a Lowe, William L4 aut
700	1	a Frayling, Timothy M4 aut
700	1	a Lawlor, Debbie A4 aut
700	1	a Freathy, Rachel M4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi4 org
773	0	t JAMAd : American Medical Association (AMA)g 315:11, s. 1129-40q 315:11<1129-40x 1538-3598x 0098-7484
856	4	u https://jamanetwork.com/journals/jama/articlepdf/2503173/joi160019.pdf
856	4 8	u https://gup.ub.gu.se/publication/248530
856	4 8	u https://doi.org/10.1001/jama.2016.1975

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By the author/editor: Tyrrell, Jessica; Richmond, Rebecc ...; Palmer, Tom M; Feenstra, Bjarke; Rangarajan, Jana ...; Metrustry, Sarah; show more...; Cavadino, Alana; Paternoster, Lav ...; Armstrong, Loren ...; De Silva, N Mane ...; Wood, Andrew R; Horikoshi, Momok ...; Geller, Frank; Myhre, Ronny; Bradfield, Jonat ...; Kreiner-Møller, ...; Huikari, Ville; Painter, Jodie N; Hottenga, Jouke- ...; Allard, Catherin ...; Berry, Diane J; Bouchard, Luigi; Das, Shikta; Evans, David M; Hakonarson, Hako ...; Hayes, M Geoffre ...; Heikkinen, Jani; Hofman, Albert; Knight, Bridget; Lind, Penelope A; McCarthy, Mark I; McMahon, George; Medland, Sarah E; Melbye, Mads; Morris, Andrew P; Nodzenski, Micha ...; Reichetzeder, Ch ...; Ring, Susan M; Sebert, Sylvain; Sengpiel, Verena ...; Sørensen, Thorki ...; Willemsen, Gonne ...; de Geus, Eco J C; Martin, Nicholas ...; Spector, Tim D; Power, Christine; Järvelin, Marjo- ...; Bisgaard, Hans; Grant, Struan F ...; Nohr, Ellen A; Jaddoe, Vincent ...; Jacobsson, Bo, 1 ...; Murray, Jeffrey ...; Hocher, Berthold; Hattersley, Andr ...; Scholtens, Denis ...; Davey Smith, Geo ...; Hivert, Marie-Fr ...; Felix, Janine F; Hyppönen, Elina; Lowe, William L; Frayling, Timoth ...; Lawlor, Debbie A; Freathy, Rachel ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Obstetrics Gynae ...

Articles in the publication: JAMA

By the university: University of Gothenburg

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