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- Lange, D (author)
Expression of TGF-beta related Smad proteins in human epithelial skin tumors.
- Article/chapterEnglish1999
Publisher, publication year, extent ...
- 1999
Numbers
- LIBRIS-ID:oai:gup.ub.gu.se/249555
- https://gup.ub.gu.se/publication/249555URI
Supplementary language notes
- Language:English
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Notes
- Members of the transforming growth factor (TGF)-beta family regulate cell growth and differentiation activating intracellular Smad proteins. Their role in skin and skin tumorigenesis is not well understood. Therefore we investigated the expression of TGF-beta type I receptor (TbetaR-I) and Smad-proteins involved in the TGF-beta-pathway, e.g. Smad2, Smad3, Smad4, Smad6 and Smad7. We examined the effects of TGF-beta1, -beta2, BMP2, BMP7 on five epithelial cell lines in vitro. TGF-beta1-mediated growth inhibition of HaCaT and HSC4 were observed with half maximal effects at approximately 7 pg ml-1 and 20 pg ml-1, respectively. However, malignant HSC2 and A431 cells were unresponsive to TGF-beta1. A differentiation was seen after 5 days in HaCaT and HSC4 cells only. We compared the reactivity with specific antisera against TbetaR-I and Smad proteins among the different skin tumors: seborrheic keratoses (SK), actinic keratoses (AK), basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). There were statistically significant differences of the ratio between the expression in tumor and that in non-tumorous epithelial cells in each tissue specimen. There was a tendency for the lower level of TbetaR-I expression of SCC compared with SK (p=0.08). This was accompanied by the decreased expression of the TbetaR-I. We found a markedly decreased expression of all antigens in BCC. conversion of normal keratinocytes to tumorigenic cells may in part be due to an acquisition of resistance to TGF-beta and loss of expression of intracellular signalling Smad proteins.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Cell- och molekylärbiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Cell and Molecular Biology hsv//eng
- Activin Receptors
- Type I
- Amino Acid Sequence
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 7
- Bone Morphogenetic Proteins
- pharmacology
- COS Cells
- Carcinoma
- Basal Cell
- metabolism
- pathology
- Carcinoma
- Squamous Cell
- metabolism
- pathology
- Cell Differentiation
- drug effects
- Cell Line
- DNA-Binding Proteins
- biosynthesis
- Humans
- Keratinocytes
- cytology
- metabolism
- Molecular Sequence Data
- Neoplasm Proteins
- biosynthesis
- Protein-Serine-Threonine Kinases
- biosynthesis
- Receptors
- Transforming Growth Factor beta
- biosynthesis
- Signal Transduction
- Skin Neoplasms
- metabolism
- pathology
- Smad2 Protein
- Smad3 Protein
- Smad4 Protein
- Smad6 Protein
- Smad7 Protein
- Trans-Activators
- biosynthesis
- Transforming Growth Factor beta
- metabolism
- pharmacology
- Tumor Cells
- Cultured
Added entries (persons, corporate bodies, meetings, titles ...)
- Persson, U (author)
- Wollina, U (author)
- ten Dijke, P (author)
- Castelli, E (author)
- Heldin, C H (author)
- Funa, Keiko,1949Gothenburg University,Göteborgs universitet,Institutionen för anatomi och cellbiologi,Institute of Anatomy and Cell Biology(Swepub:gu)xfunke (author)
- Göteborgs universitetInstitutionen för anatomi och cellbiologi (creator_code:org_t)
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- In:International journal of oncology14:6, s. 1049-561019-6439
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