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IFN type I and II i...
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Lundell, Anna-Carin,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
(author)
IFN type I and II induce BAFF secretion from human decidual stromal cells
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-01-06
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Springer Science and Business Media LLC,2017
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LIBRIS-ID:oai:gup.ub.gu.se/250070
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https://gup.ub.gu.se/publication/250070URI
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https://doi.org/10.1038/srep39904DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:134965407URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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B cell activating factor (BAFF) is a critical cytokine for maturation of immature B cells. In murine lymph nodes, BAFF is mainly produced by podoplanin-expressing stromal cells. We have previously shown that circulating BAFF levels are maximal at birth, and that farmers' children exhibit higher BAFF levels in cord blood than non-farmers' children. Here, we sought to investigate whether maternal-derived decidual stromal cells from placenta secrete BAFF and examine what factors could stimulate this production. We found that podoplanin is expressed in decidua basalis and in the underlying villous tissue as well as on isolated maternal-derived decidual stromal cells. Decidual stromal cells produced BAFF when stimulated with IFN-gamma and IFN-alpha, and NK cells and NK-T-like cells competent of IFN-gamma production were isolated from the decidua. Finally, B cells at different maturational stages are present in decidua and all expressed BAFF-R, while stromal cells did not. These findings suggest that decidual stromal cells are a cellular source of BAFF for B cells present in decidua during pregnancy.
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Nordström, Inger,1958Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xningm
(author)
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Andersson, Kerstin,1962Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xandke
(author)
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Lundqvist, Christina,1988Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xluchl
(author)
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Telemo, Esbjörn,1953Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xteles
(author)
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Nava, S.Karolinska Institutet
(author)
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Kaipe, H.Karolinska Institutet
(author)
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Rudin, Anna,1961Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xrudan
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för reumatologi och inflammationsforskning
(creator_code:org_t)
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In:Scientific Reports: Springer Science and Business Media LLC72045-2322
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Karolinska Institutet