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Meta and pooled analysis of European coeliac disease data
- Barbron, Marie-Claude (author)
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- Nilsson, Staffan, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematisk statistik,Department of Mathematical Statistics,Chalmers tekniska högskola,Chalmers University of Technology,University of Gothenburg
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- Adamovic, Svetlana, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children,University of Gothenburg
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- Ciclitera, Paul (author)
- Sollid, Ludvig M (author)
- Partanen, Jukka (author)
- Greco, Luigi (author)
- Clerget-Darpoux, Francoise (author)
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- (creator_code:org_t)
- 2003-10-22
- 2003
- English.
- In: European Journal of Human Genetics. - : Springer Science and Business Media LLC. - 1018-4813 .- 1476-5438. ; 11:11, s. 828-834
- Journal article (peer-reviewed)
Abstract
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- Four full genome scans have been carried out by the partners of the European cluster on coeliac disease as well as follow-up studies of candidate regions. No region outside HLA showed significant linkage to the disease in any single study. We first applied a meta-analysis based on a modification of Genome Screen Meta-Analysis to take into account the different linkage statistics, the arbitrariness of bin cutoff points, as well as the sample size of each study. We then performed a pooled linkage analysis of all families and raw genotypes. Besides the HLA region, already known to harbour a risk factor for coeliac disease, both approaches leave very little doubt on the presence of a genetic risk factor in the 5q31-33 region. This region was suggested by several individual studies, but did not reach statistical values high enough to be conclusive when data sets were analysed separately.
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