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Vagal Blocking for ...
Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action
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Johannessen, H. (author)
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- Revesz, David (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Kodama, Y. (author)
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Cassie, N. (author)
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- Skibicka, Karolina P (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Barrett, P. (author)
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- Dickson, Suzanne L., 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Holst, J. (author)
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Rehfeld, J. (author)
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van der Plasse, G. (author)
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Adan, R. (author)
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Kulseng, B. (author)
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- Ben-Menachem, Elinor, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Zhao, C. M. (author)
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Chen, D. (author)
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(creator_code:org_t)
- 2016-08-30
- 2017
- English.
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In: Obesity Surgery. - : Springer Science and Business Media LLC. - 0960-8923 .- 1708-0428. ; 27:1, s. 177-185
- Related links:
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Abstract
Subject headings
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- Recently, the US FDA has approved "vagal blocking therapy or vBLocA (R) therapy" as a new treatment for obesity. The aim of the present study was to study the mechanism-of-action of "VBLOC" in rat models. Rats were implanted with VBLOC, an intra-abdominal electrical device with leads placed around gastric vagal trunks through an abdominal incision and controlled by wireless device. Body weight, food intake, hunger/satiety, and metabolic parameters were monitored by a comprehensive laboratory animal monitoring system. Brain-gut responses were analyzed physiologically. VBLOC reduced body weight and food intake, which was associated with increased satiety but not with decreased hunger. Brain activities in response to VBLOC included increased gene expression of leptin and CCKb receptors, interleukin-1 beta, tumor necrosis factor, and transforming growth factor beta 1 in the brainstem; increased CCK, somatostatin, and tyrosine hydroxylase in the hippocampus; increased NPY, AgRP, and Foxa2 in the hypothalamus; and reduced CCKb receptor, melanocortin 4 receptor, and insulin receptor in the hypothalamus. Plasma concentrations of CCK, gastrin, glucagon, GLP-1, and PYY and gastric acid secretion were unchanged in response to VBLOC. Based on the present study, we may suggest that VBLOC induces satiety through vagal signaling, leading to reduced food intake and loss of body weight.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Body weight
- Food intake
- Gut-brain axis
- Rats
- Vagus nerve
- vagus nerve-stimulation
- food-intake
- body-weight
- feeding-behavior
- rats
- hippocampus
- surgery
- mice
- receptor
- acid
- Surgery
- rloni g
- 1986
- physiology & behavior
- v38
- p321
- BAS HT
- 1994
- YALE JOURNAL OF BIOLOGY AND MEDICINELester Dragstedt Centenary Symposium
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Johannessen, H.
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Revesz, David
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Kodama, Y.
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Cassie, N.
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Skibicka, Karoli ...
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Barrett, P.
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show more...
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Dickson, Suzanne ...
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Holst, J.
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Rehfeld, J.
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van der Plasse, ...
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Adan, R.
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Kulseng, B.
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Ben-Menachem, El ...
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Zhao, C. M.
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Chen, D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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Obesity Surgery
- By the university
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University of Gothenburg