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Meta-analysis of ge...
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins
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Postmus, I. (author)
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Warren, H. R. (author)
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Trompet, S. (author)
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show more...
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Arsenault, B. J. (author)
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Avery, C. L. (author)
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Bis, J. C. (author)
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Chasman, D. I. (author)
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de Keyser, C. E. (author)
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Deshmukh, H. A. (author)
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Evans, D. S. (author)
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Feng, Q. P. (author)
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Li, X. H. (author)
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Smit, R. A. J. (author)
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Smith, A. V. (author)
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Sun, F. G. (author)
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Taylor, K. D. (author)
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Arnold, A. M. (author)
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Barnes, M. R. (author)
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Barratt, B. J. (author)
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Betteridge, J. (author)
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Boekholdt, S. M. (author)
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Boerwinkle, E. (author)
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Buckley, B. M. (author)
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Chen, Y. D. I. (author)
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de Craen, A. J. M. (author)
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Cummings, S. R. (author)
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Denny, J. C. (author)
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Dube, M. P. (author)
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Durrington, P. N. (author)
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Eiriksdottir, G. (author)
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Ford, I. (author)
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Guo, X. Q. (author)
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Harris, T. B. (author)
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Heckbert, S. R. (author)
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Hofman, A. (author)
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Hovingh, G. K. (author)
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Kastelein, J. J. P. (author)
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Launer, L. J. (author)
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Liu, C. T. (author)
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Liu, Y. M. (author)
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Lumley, T. (author)
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McKeigue, P. M. (author)
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Munroe, P. B. (author)
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Neil, A. (author)
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Nickerson, D. A. (author)
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- Nyberg, Fredrik, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
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O'Brien, E. (author)
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O'Donnell, C. J. (author)
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Post, W. (author)
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Poulter, N. (author)
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Vasan, R. S. (author)
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Rice, K. (author)
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Rich, S. S. (author)
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Rivadeneira, F. (author)
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Sattar, N. (author)
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Sever, P. (author)
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Shaw-Hawkins, S. (author)
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Shields, D. C. (author)
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Slagboom, P. E. (author)
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Smith, N. L. (author)
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Smith, J. D. (author)
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Sotoodehnia, N. (author)
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Stanton, A. (author)
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Stott, D. J. (author)
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Stricker, B. H. (author)
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Sturmer, T. (author)
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Uitterlinden, A. G. (author)
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Wei, W. Q. (author)
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Westendorp, R. G. J. (author)
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Whitsel, E. A. (author)
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Wiggins, K. L. (author)
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Wilke, R. A. (author)
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Ballantyne, C. M. (author)
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Colhoun, H. M. (author)
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Cupples, L. A. (author)
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Franco, O. H. (author)
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Gudnason, V. (author)
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Hitman, G. (author)
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Palmer, C. N. A. (author)
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Psaty, B. M. (author)
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Ridker, P. M. (author)
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Stafford, J. M. (author)
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Stein, C. M. (author)
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Tardif, J. C. (author)
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Caulfield, M. J. (author)
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Jukema, J. W. (author)
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Rotter, J. I. (author)
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Krauss, R. M. (author)
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(creator_code:org_t)
- 2016-09-01
- 2016
- English.
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In: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 53:12, s. 835-45
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Background In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Interindividual variation in HDL-C response to statins may be partially explained by genetic variation. Methods and results We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1x10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p<5x10(-8)) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment. Conclusions Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- density-lipoprotein cholesterol
- transfer protein gene
- coronary
- atherosclerosis
- cardiovascular events
- lowering response
- ldl
- cholesterol
- atorvastatin
- disease
- risk
- lipids
- Genetics & Heredity
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Postmus, I.
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Warren, H. R.
-
Trompet, S.
-
Arsenault, B. J.
-
Avery, C. L.
-
Bis, J. C.
-
show more...
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Chasman, D. I.
-
de Keyser, C. E.
-
Deshmukh, H. A.
-
Evans, D. S.
-
Feng, Q. P.
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Li, X. H.
-
Smit, R. A. J.
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Smith, A. V.
-
Sun, F. G.
-
Taylor, K. D.
-
Arnold, A. M.
-
Barnes, M. R.
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Barratt, B. J.
-
Betteridge, J.
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Boekholdt, S. M.
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Boerwinkle, E.
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Buckley, B. M.
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Chen, Y. D. I.
-
de Craen, A. J. ...
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Cummings, S. R.
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Denny, J. C.
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Dube, M. P.
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Durrington, P. N ...
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Eiriksdottir, G.
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Ford, I.
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Guo, X. Q.
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Harris, T. B.
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Heckbert, S. R.
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Hofman, A.
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Hovingh, G. K.
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Kastelein, J. J. ...
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Launer, L. J.
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Liu, C. T.
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Liu, Y. M.
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Lumley, T.
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McKeigue, P. M.
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Munroe, P. B.
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Neil, A.
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Nickerson, D. A.
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Nyberg, Fredrik, ...
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O'Brien, E.
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O'Donnell, C. J.
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Post, W.
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Poulter, N.
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Vasan, R. S.
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Rice, K.
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Rich, S. S.
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Rivadeneira, F.
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Sattar, N.
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Sever, P.
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Shaw-Hawkins, S.
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Shields, D. C.
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Slagboom, P. E.
-
Smith, N. L.
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Smith, J. D.
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Sotoodehnia, N.
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Stanton, A.
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Stott, D. J.
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Stricker, B. H.
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Sturmer, T.
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Uitterlinden, A. ...
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Wei, W. Q.
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Westendorp, R. G ...
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Whitsel, E. A.
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Wiggins, K. L.
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Wilke, R. A.
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Ballantyne, C. M ...
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Colhoun, H. M.
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Cupples, L. A.
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Franco, O. H.
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Gudnason, V.
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Hitman, G.
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Palmer, C. N. A.
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Psaty, B. M.
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Ridker, P. M.
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Stafford, J. M.
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Stein, C. M.
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Tardif, J. C.
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Caulfield, M. J.
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Jukema, J. W.
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Rotter, J. I.
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Krauss, R. M.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Journal of Medic ...
- By the university
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University of Gothenburg