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Amyloid and Tau PET...
Amyloid and Tau PET Demonstrate Region-Specific Associations in Normal Older People.
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Lockhart, Samuel N (author)
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- Schöll, Michael, 1980 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
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Baker, Suzanne L (author)
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Ayakta, Nagehan (author)
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Swinnerton, Kaitlin N (author)
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Bell, Rachel K (author)
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Mellinger, Taylor J (author)
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Shah, Vyoma D (author)
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O'Neil, James P (author)
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Janabi, Mustafa (author)
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Jagust, William J (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: NeuroImage. - : Elsevier BV. - 1095-9572 .- 1053-8119. ; 150, s. 191-199
- Related links:
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https://europepmc.or...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- β-amyloid (Aβ) and tau pathology become increasingly prevalent with age, however, the spatial relationship between the two pathologies remains unknown. We examined local (same region) and non-local (different region) associations between these 2 aggregated proteins in 46 normal older adults using [(18)F]AV-1451 (for tau) and [(11)C]PiB (for Aβ) positron emission tomography (PET) and 1.5T magnetic resonance imaging (MRI) images. While local voxelwise analyses showed associations between PiB and AV-1451 tracer largely in the temporal lobes, k-means clustering revealed that some of these associations were driven by regions with low tracer retention. We followed this up with a whole-brain region-by-region (local and non-local) partial correlational analysis. We calculated each participant's mean AV-1451 and PiB uptake values within 87 regions of interest (ROI). Pairwise ROI analysis demonstrated many positive PiB-AV-1451 associations. Importantly, strong positive partial correlations (controlling for age, sex, and global gray matter fraction, p < .01) were identified between PiB in multiple regions of association cortex and AV-1451 in temporal cortical ROIs. There were also less frequent and weaker positive associations of regional PiB with frontoparietal AV-1451 uptake. Particularly in temporal lobe ROIs, AV-1451 uptake was strongly predicted by PiB across multiple ROI locations. These data indicate that Aβ and tau pathology show significant local and non-local regional associations among cognitively normal elderly, with increased PiB uptake throughout the cortex correlating with increased temporal lobe AV-1451 uptake. The spatial relationship between Aβ and tau accumulation does not appear to be specific to Aβ location, suggesting a regional vulnerability of temporal brain regions to tau accumulation regardless of where Aβ accumulates.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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NeuroImage
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- By the author/editor
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Lockhart, Samuel ...
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Schöll, Michael, ...
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Baker, Suzanne L
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Ayakta, Nagehan
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Swinnerton, Kait ...
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Bell, Rachel K
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show more...
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Mellinger, Taylo ...
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Shah, Vyoma D
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O'Neil, James P
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Janabi, Mustafa
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Jagust, William ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
- Articles in the publication
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NeuroImage
- By the university
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University of Gothenburg