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Body composition an...
Body composition and quality of life as markers of the efficacy of growth hormone replacement therapy in adults.
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Svensson, J (author)
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- Johannsson, Gudmundur, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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Bengtsson, B A (author)
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(creator_code:org_t)
- 2001
- 2001
- English.
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In: Hormone research. - 0301-0163. ; 55 Suppl 2, s. 55-60
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https://gup.ub.gu.se...
Abstract
Subject headings
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- Growth hormone (GH) replacement therapy in GH-deficient adults should be initiated with a low dose, independent of body weight or body surface area. Measurements of serum insulin-like growth factor I (IGF-I) concentrations, as well as clinical examinations aimed at detecting signs of fluid excess, are important as safety markers to avoid overtreatment with GH. At present, there is no optimal marker for the long-term efficacy of GH replacement therapy. The long-term maintenance dose of GH should, therefore, be titrated in each individual based on the clinical response, with the aim of normalizing body hydration, other measurements of body composition, quality of life and well-being, and biochemical indices such as serum IGF-I concentration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Adult
- Biomarkers
- Body Composition
- Growth Hormone
- administration & dosage
- adverse effects
- therapeutic use
- Hormone Replacement Therapy
- Humans
- Outcome Assessment (Health Care)
- methods
- Quality of Life
Publication and Content Type
- ref (subject category)
- for (subject category)
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