Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects. Swedish Study Group for Growth Hormone Treatment in Children.

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Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine (author)

Discontinuation of growth hormone (GH) treatment: metabolic effects in GH-deficient and GH-sufficient adolescent patients compared with control subjects. Swedish Study Group for Growth Hormone Treatment in Children.

Article/chapterEnglish1999

Publisher, publication year, extent ...

The Endocrine Society,1999

Numbers

LIBRIS-ID:oai:gup.ub.gu.se/251257
https://gup.ub.gu.se/publication/251257URI
https://doi.org/10.1210/jcem.84.12.6176DOI

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Language:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

The need for continuing GH replacement in patients with childhood-onset GH deficiency continuing into adulthood has been recognized. The metabolic consequences of discontinuing GH in adolescent patients with childhood-onset GH deficiency and short stature were examined over a period of 2 yr. Forty adolescents (aged 16-21 yr) receiving GH treatment for more than 3 yr and 16 closely matched healthy controls were studied. After a baseline visit, GH treatment was discontinued. The patients were then examined with the same protocol once a year for 2 yr. Twenty-one patients had severe GH deficiency (GHD) into adulthood, whereas 19 patients were regarded as having sufficient endogenous GH secretion (GHS). After 2 yr without GH treatment, the serum insulin-like growth factor I level was lower in GHD than in both GHS and control subjects. Both before and 2 yr after GH treatment was discontinued, serum concentrations of total cholesterol (C), low density lipoprotein C, and apolipoprotein B were higher in the GHD than in both GHS and control subjects. Serum concentrations of high density lipoprotein C decreased in the GHD group and increased in the other 2 study groups. The amount of total body and abdominal fat mass throughout the study and the increment in these masses were more marked in the GHD than in the GHS and control subjects when GH treatment was discontinued. The discontinuation of GH therapy in adolescents with severe GHD continuing into adulthood results over a period of 2 yr in the accumulation of important cardiovascular risk factors that are associated with GHD in adults.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Adolescent
Adult
Apolipoproteins B
blood
Blood Glucose
metabolism
Blood Pressure
Body Composition
Cardiovascular Diseases
blood
Cholesterol
blood
Cholesterol
HDL
blood
Cholesterol
LDL
blood
Female
Human Growth Hormone
deficiency
therapeutic use
Humans
Insulin-Like Growth Factor Binding Protein 3
blood
Insulin-Like Growth Factor I
metabolism
Lipids
blood
Male
Prospective Studies
Risk Factors

Added entries (persons, corporate bodies, meetings, titles ...)

Albertsson-Wikland, Kerstin,1947 (author)
Bengtsson, B A (author)
Göteborgs universitetInstitutionen för invärtesmedicin (creator_code:org_t)

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In:The Journal of clinical endocrinology and metabolism: The Endocrine Society84:12, s. 4516-240021-972X1945-7197

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