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Risk of stroke in chronic heart failure patients with preserved ejection fraction, but without atrial fibrillation: analysis of the CHARM-Preserved and I-Preserve trials

Abdul-Rahim, A. H. (author)
Perez, A. C. (author)
MacIsaac, R. L. (author)
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Jhund, P. S. (author)
Claggett, B. L. (author)
Carson, P. E. (author)
Komajda, M. (author)
McKelvie, R. S. (author)
Zile, M. R. (author)
Swedberg, Karl, 1944 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
Yusuf, S. (author)
Pfeffer, M. A. (author)
Solomon, S. D. (author)
Lip, G. Y. H. (author)
Lees, K. R. (author)
McMurray, J. J. V. (author)
Candesartan Heart Failure Assessme; Irbesartan Heart Failure, Preserved (author)
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 (creator_code:org_t)
2016-11-13
2017
English.
In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 38:10, s. 742-750
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Aims The incidence and predictors of stroke in patients with heart failure and preserved ejection fraction (HF-PEF), but without atrial fibrillation (AF), are unknown. We described the incidence of stroke in HF-PEF patients with and without AF and predictors of stroke in those without AF. Methods and results We pooled data from the CHARM-Preserved and I-Preserve trials. Using Cox regression, we derived a model for stroke in patients without AF in this cohort and compared its performance with a published model in heart failure patients with reduced ejection fraction (HF-REF)-predictive variables: age, body mass index, New York Heart Association class, history of stroke, and insulin-treated diabetes. The two stroke models were compared and Kaplan-Meier curves for stroke estimated. The risk model was validated in a third HF-PEF trial. Of the 6701 patients, 4676 did not have AF. Stroke occurred in 124 (6.1%) with AF and in 171 (3.7%) without AF (rates 1.80 and 1.00 per 100 patient-years, respectively). There was no difference in performance of the stroke model derived in the HF-PEF cohort and the published HF-REF model (c-index 0.71, 95% confidence interval 0.57-0.84 vs. 0.73, 0.59-0.85, respectively) as the predictive variables overlapped. The model performed well in the validation cohort (0.86, 0.62-0.99). The rate of stroke in patients in the upper third of risk approximated to that in patients with AF (1.60 and 1.80 per 100 patient-years, respectively). Conclusions A small number of clinical variables identify a subset of patients with HF-PEF, but without AF, at elevated risk of stroke.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

Heart failure with preserved ejection fraction
Stroke
Risk-factors
left-ventricular dysfunction
randomized-trial
controlled rosuvastatin
multinational trial
systolic function
sinus rhythm
warfarin
epidemiology
hypertension
outcomes
Cardiovascular System & Cardiology

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ref (subject category)
art (subject category)

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