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- Charney, A. W. (author)
Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-01-10
- Springer Science and Business Media LLC,2017
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- LIBRIS-ID:oai:gup.ub.gu.se/252320
- https://gup.ub.gu.se/publication/252320URI
- https://doi.org/10.1038/tp.2016.242DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:135377163URI
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- Language:English
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- We performed a genome-wide association study of 6447 bipolar disorder (BD) cases and 12 639 controls from the International Cohort Collection for Bipolar Disorder (ICCBD). Meta-analysis was performed with prior results from the Psychiatric Genomics Consortium Bipolar Disorder Working Group for a combined sample of 13 902 cases and 19 279 controls. We identified eight genome-wide significant, associated regions, including a novel associated region on chromosome 10 (rs10884920; P = 3.28 x 10(-8)) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1). Our large sample size allowed us to test the heritability and genetic correlation of BD subtypes and investigate their genetic overlap with schizophrenia and major depressive disorder. We found a significant difference in heritability of the two most common forms of BD (BD I SNP-h(2) = 0.35; BD II SNP-h(2) = 0.25; P = 0.02). The genetic correlation between BD I and BD II was 0.78, whereas the genetic correlation was 0.97 when BD cohorts containing both types were compared. In addition, we demonstrated a significantly greater load of polygenic risk alleles for schizophrenia and BD in patients with BD I compared with patients with BD II, and a greater load of schizophrenia risk alleles in patients with the bipolar type of schizoaffective disorder compared with patients with either BD I or BD II. These results point to a partial difference in the genetic architecture of BD subtypes as currently defined.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- genome-wide association
- spectrum disorder
- ii disorder
- risk loci
- schizophrenia
- family
- depression
- unipolar
- illness
- susceptibility
- Psychiatry
- rshon es
- 1982
- archives of general psychiatry
- v39
- p1157
- guffin p
- 1991
- archives of general psychiatry
- v48
- p764
Added entries (persons, corporate bodies, meetings, titles ...)
- Ruderfer, D. M. (author)
- Stahl, E. A. (author)
- Moran, J. L.Karolinska Institutet (author)
- Chambert, K. (author)
- Belliveau, R. A. (author)
- Forty, L. (author)
- Gordon-Smith, K. (author)
- Di Florio, A. (author)
- Lee, P. H. (author)
- Bromet, E. J. (author)
- Buckley, P. F. (author)
- Escamilla, M. A. (author)
- Fanous, A. H. (author)
- Fochtmann, L. J. (author)
- Lehrer, D. S. (author)
- Malaspina, D. (author)
- Marder, S. R.Karolinska Institutet (author)
- Morley, C. P. (author)
- Nicolini, H. (author)
- Perkins, D. O. (author)
- Rakofsky, J. J. (author)
- Rapaport, M. H. (author)
- Medeiros, H.Karolinska Institutet (author)
- Sobell, J. L. (author)
- Green, E. K. (author)
- Backlund, L.Karolinska Institutet (author)
- Bergen, S. E.Karolinska Institutet (author)
- Jureus, A.Karolinska Institutet (author)
- Schalling, M. (author)
- Lichtenstein, P.Karolinska Institutet (author)
- Roussos, P. (author)
- Knowles, J. A. (author)
- Jones, I. (author)
- Jones, L. A. (author)
- Hultman, C. M. (author)
- Perlis, R. H. (author)
- Purcell, S. M. (author)
- McCarroll, S. A. (author)
- Pato, C. N. (author)
- Pato, M. T. (author)
- Craddock, N. (author)
- Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt (author)
- Smoller, J. W. (author)
- Sklar, P. (author)
- Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)
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- In:Translational Psychiatry: Springer Science and Business Media LLC7:12158-3188
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- Charney, A. W.
- Ruderfer, D. M.
- Stahl, E. A.
- Moran, J. L.
- Chambert, K.
- Belliveau, R. A.
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- Forty, L.
- Gordon-Smith, K.
- Di Florio, A.
- Lee, P. H.
- Bromet, E. J.
- Buckley, P. F.
- Escamilla, M. A.
- Fanous, A. H.
- Fochtmann, L. J.
- Lehrer, D. S.
- Malaspina, D.
- Marder, S. R.
- Morley, C. P.
- Nicolini, H.
- Perkins, D. O.
- Rakofsky, J. J.
- Rapaport, M. H.
- Medeiros, H.
- Sobell, J. L.
- Green, E. K.
- Backlund, L.
- Bergen, S. E.
- Jureus, A.
- Schalling, M.
- Lichtenstein, P.
- Roussos, P.
- Knowles, J. A.
- Jones, I.
- Jones, L. A.
- Hultman, C. M.
- Perlis, R. H.
- Purcell, S. M.
- McCarroll, S. A.
- Pato, C. N.
- Pato, M. T.
- Craddock, N.
- Landén, Mikael, ...
- Smoller, J. W.
- Sklar, P.
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