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FGF21 Administratio...
FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice
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Fu, Z. J. (author)
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Gong, Y. (author)
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Liegl, R. (author)
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Wang, Z. X. (author)
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Liu, C. H. (author)
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Meng, S. S. (author)
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Burnim, S. B. (author)
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Saba, N. J. (author)
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Fredrick, T. W. (author)
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Morss, P. C. (author)
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- Hellström, Ann, 1959 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Talukdar, S. (author)
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Smith, L. E. H. (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 18:7, s. 1606-1613
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pathological neovascularization, a leading cause of blindness, is seen in retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration. Using a mouse model of hypoxia-driven retinal neovascularization, wefind that fibroblast growth factor 21 (FGF21) administration suppresses, and FGF21 deficiency worsens, retinal neovessel growth. The protective effect of FGF21 against neovessel growth was abolished in adiponectin (APN)-deficient mice. FGF21 administration also decreased neovascular lesions in two models of neovascular age-related macular degeneration: very-low-density lipoprotein-receptor-deficient mice with retinal angiomatous proliferation and laser-induced choroidal neovascularization. FGF21 inhibited tumor necrosis alpha (TNF-alpha) expression but did not alter Vegfa expression in neovascular eyes. These data suggest that FGF21 may be a therapeutic target for pathologic vessel growth in patients with neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, and age-related macular degeneration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Keyword
- proliferative diabetic-retinopathy
- oxygen-induced retinopathy
- endothelial growth-factor
- brown adipose-tissue
- macular degeneration
- beta-klotho
- tnf-alpha
- adiponectin
- type-2
- prematurity
- Cell Biology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fu, Z. J.
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Gong, Y.
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Liegl, R.
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Wang, Z. X.
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Liu, C. H.
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Meng, S. S.
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show more...
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Burnim, S. B.
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Saba, N. J.
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Fredrick, T. W.
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Morss, P. C.
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Hellström, Ann, ...
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Talukdar, S.
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Smith, L. E. H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Ophthalmology
- Articles in the publication
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Cell Reports
- By the university
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University of Gothenburg