Search: onr:"swepub:oai:gup.ub.gu.se/252611" >
Improved Cerebrospi...
Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes
-
van Doorn, Ljcv (author)
-
Gispert, J. D. (author)
-
Kuiperij, H. B. (author)
-
show more...
-
Claassen, Jahr (author)
-
Arighi, A. (author)
-
Baldeiras, I. (author)
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
-
Bozzali, M. (author)
-
Castelo-Branco, M. (author)
-
Cavedo, E. (author)
-
Emek-Savas, D. D. (author)
-
Eren, E. (author)
-
Eusebi, P. (author)
-
Farotti, L. (author)
-
Fenoglio, C. (author)
-
Ormaechea, J. F. (author)
-
Freund-Levi, Y. (author)
-
Frisoni, G. B. (author)
-
Galimberti, D. (author)
-
Genc, S. (author)
-
Greco, V. (author)
-
Hampel, H. (author)
-
Herukka, S. K. (author)
-
Liu, Y. W. (author)
-
Llado, A. (author)
-
Lleo, A. (author)
-
Nobili, F. M. (author)
-
Oguz, K. K. (author)
-
Parnetti, L. (author)
-
Pereira, J. (author)
-
Picco, A. (author)
-
Pikkarainen, M. (author)
-
de Oliveira, C. R. (author)
-
Saka, E. (author)
-
Salvadori, N. (author)
-
Sanchez-Valle, R. (author)
-
Santana, I. (author)
-
Scarpini, E. (author)
-
Scheltens, P. (author)
-
Soininen, H. (author)
-
Tarducci, R. (author)
-
Teunissen, C. (author)
-
Tsolaki, M. (author)
-
Urbani, A. (author)
-
Vilaplana, E. (author)
-
Visser, P. J. (author)
-
Wallin, A. K. (author)
-
Yener, G. (author)
-
Molinuevo, J. L. (author)
-
Meulenbroek, O. (author)
-
Verbeek, M. M. (author)
-
show less...
-
(creator_code:org_t)
- IOS Press, 2017
- 2017
- English.
-
In: Journal of Alzheimers Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 56:2, s. 543-555
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., A beta(42), total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF A beta(42) levels inversely correlated to VV/TIV in the whole study population (A beta(42): r = -0.28; p < 0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r = -0.15; p-tau: r = -0.13; both p < 0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF A beta(42) alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF A beta(42) levels.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- amyloid biomarkers
- cerebrospinal fluid
- lateral ventricles
- tau protein
- mild cognitive impairment
- ad-csf-index
- national institute
- association
- workgroups
- diagnostic guidelines
- brain atrophy
- biomarkers
- dementia
- recommendations
- tau
- Neurosciences & Neurology
- heltens p
- 1992
- journal of neurology neurosurgery and psychiatry
- v55
- p967
- khann g
- 1984
- neurology
- v34
- p939
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
van Doorn, Ljcv
-
Gispert, J. D.
-
Kuiperij, H. B.
-
Claassen, Jahr
-
Arighi, A.
-
Baldeiras, I.
-
show more...
-
Blennow, Kaj, 19 ...
-
Bozzali, M.
-
Castelo-Branco, ...
-
Cavedo, E.
-
Emek-Savas, D. D ...
-
Eren, E.
-
Eusebi, P.
-
Farotti, L.
-
Fenoglio, C.
-
Ormaechea, J. F.
-
Freund-Levi, Y.
-
Frisoni, G. B.
-
Galimberti, D.
-
Genc, S.
-
Greco, V.
-
Hampel, H.
-
Herukka, S. K.
-
Liu, Y. W.
-
Llado, A.
-
Lleo, A.
-
Nobili, F. M.
-
Oguz, K. K.
-
Parnetti, L.
-
Pereira, J.
-
Picco, A.
-
Pikkarainen, M.
-
de Oliveira, C. ...
-
Saka, E.
-
Salvadori, N.
-
Sanchez-Valle, R ...
-
Santana, I.
-
Scarpini, E.
-
Scheltens, P.
-
Soininen, H.
-
Tarducci, R.
-
Teunissen, C.
-
Tsolaki, M.
-
Urbani, A.
-
Vilaplana, E.
-
Visser, P. J.
-
Wallin, A. K.
-
Yener, G.
-
Molinuevo, J. L.
-
Meulenbroek, O.
-
Verbeek, M. M.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Journal of Alzhe ...
- By the university
-
University of Gothenburg