Androgen Receptor Signaling in Salivary Gland Cancer

• Salivary gland cancers comprise a small subset of human malignancies, and are classified into multiple subtypes that exhibit diverse histology, molecular biology and clinical presentation. Local disease is potentially curable with surgery, which may be combined with adjuvant radiotherapy. However, metastatic or unresectable tumors rarely respond to chemotherapy and carry a poorer prognosis. Recent molecular studies have shown evidence of androgen receptor signaling in several types of salivary gland cancer, mainly salivary duct carcinoma. Successful treatment with anti-androgen therapy in other androgen receptor-positive malignancies such as prostate and breast cancer has inspired researchers to investigate this treatment in salivary gland cancer as well. In this review, we describe the prevalence, biology, and therapeutic implications of androgen receptor signaling in salivary gland cancer.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

salivary gland cancer

androgen receptor

salivary duct carcinoma

androgen-deprivation therapy (ADT)

duct carcinoma

prostate-cancer

deprivation therapy

molecular

characterization

mucoepidermoid carcinoma

somatic mutations

breast-cancer

expression

tumors

apocrine

Oncology

winter jar

1991

journal of histochemistry & cytochemistry

v39

p927

Publication and Content Type

ref (subject category)

art (subject category)