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Benefits of resista...
Benefits of resistance exercise in lean women with fibromyalgia: involvement of IGF-1 and leptin
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- Bjersing, Jan, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden; Sahlgrens University Hospital, Sweden
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- Larsson, Anette, 1970 (author)
- Gothenburg University,Göteborgs universitet,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,University of Gothenburg Centre for person-centred care (GPCC),Institute of Medicine, Department of Rheumatology and Inflammation Research,University of Gothenburg, Sweden
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- Palstam, Annie, 1981 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Centrum för personcentrerad vård vid Göteborgs universitet (GPCC),Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg Centre for person-centred care (GPCC),Sahlgrenska Academy, University of Gothenburg,University of Gothenburg, Sweden
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- Ernberg, M. (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Bileviciute-Ljungar, I. (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Lofgren, M. (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Gerdle, Björn (author)
- Linköpings universitet,Avdelningen för samhällsmedicin,Medicinska fakulteten,Region Östergötland, Smärt och rehabiliteringscentrum
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- Kosek, Eva (author)
- Karolinska Institutet,Karolinska Institute, Sweden; Stockholm Spine Centre, Sweden
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- Mannerkorpi, Kaisa, 1955 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institutionen för neurovetenskap och fysiologi, sektionen för hälsa och rehabilitering,Institute of Medicine, Department of Rheumatology and Inflammation Research,Institute of Neuroscience and Physiology, Department of Health and Rehabilitation,University of Gothenburg, Sweden; Sahlgrenska University Hospital, Sweden
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(creator_code:org_t)
- 2017-03-14
- 2017
- English.
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In: Bmc Musculoskeletal Disorders. - : Springer Science and Business Media LLC. - 1471-2474. ; 18:106
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Abstract
Subject headings
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- Background: Chronic pain and fatigue improves by exercise in fibromyalgia (FM) but underlying mechanisms are not known. Obesity is increased among FM patients and associates with higher levels of pain. Symptom improvement after aerobic exercise is affected by body mass index (BMI) in FM. Metabolic factors such as insulin-like growth factor 1 (IGF1) and leptin may be involved. In this study, the aim was to evaluate the role of metabolic factors in lean, overweight and obese women during resistance exercise, in relation to symptom severity and muscle strength in women with FM. Methods: Forty-three women participated in supervised progressive resistance exercise, twice weekly for 15-weeks. Serum free and total IGF-1, IGF-binding protein 3 (IGFBP3), adiponectin, leptin and resistin were determined at baseline and after 15-weeks. Level of current pain was rated on a visual analogue scale (0-100 mm). Level of fatigue was rated by multidimensional fatigue inventory (MFI-20) subscale general fatigue (MFIGF). Knee extension force, elbow flexion force and handgrip force were assessed by dynamometers. Results: Free IGF-1 (p = 0.047), IGFBP3 (p = 0.025) and leptin (p = 0.008) were significantly decreased in lean women (n = 18), but not in the overweight (n = 17) and the obese (n = 8). Lean women with FM benefited from resistance exercise with improvements in current pain (p= 0.039, n = 18), general fatigue (MFIGF, p = 0.022, n = 18) and improved elbow-flexion force (p = 0.017, n = 18). In overweight and obese women with FM there was no significant improvement in pain or fatigue but an improvement in elbow flexion (p = 0.049; p = 0.012) after 15 weeks of resistance exercise. Conclusion: The clearest clinical response to resistance exercise was found in lean patients with FM. In these individuals, individualized resistance exercise was followed by changes in IGF-1 and leptin, reduced pain, fatigue and improved muscular strength. In overweight and obese women FM markers of metabolic signaling and clinical symptoms were unchanged, but strength was improved in the upper limb. Resistance exercise combined with dietary interventions might benefit patients with FM and overweight.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
Keyword
- randomized controlled-trial
- body-mass index
- growth-factor-i
- chronic-fatigue-syndrome
- quality-of-life
- physical-exercise
- hippocampal neurogenesis
- brain plasticity
- healthy controls
- persistent
- pain
- Orthopedics
- Rheumatology
- Resistance Exercise
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bjersing, Jan, 1 ...
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Larsson, Anette, ...
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Palstam, Annie, ...
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Ernberg, M.
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Bileviciute-Ljun ...
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Lofgren, M.
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Gerdle, Björn
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Kosek, Eva
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Mannerkorpi, Kai ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Physiotherapy
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Bmc Musculoskele ...
- By the university
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University of Gothenburg
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Karolinska Institutet
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Högskolan Dalarna
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Uppsala University
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Linköping University