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Alopecia areata tot...
Alopecia areata totalis and universalis: a multicenter review of 132 patients in Spain
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Vano-Galvan, S. (author)
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Fernandez-Crehuet, P. (author)
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Grimalt, R. (author)
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Garcia-Hernandez, M. J. (author)
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Rodrigues-Barata, R. (author)
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Arias-Santiago, S. (author)
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Molina-Ruiz, A. (author)
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Garcia-Lora, E. (author)
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Dominguez-Cruz, J. (author)
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Brugues, A. (author)
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Ferrando, J. (author)
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Serrano-Falcon, C. (author)
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Serrano, S. (author)
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- Paoli, John, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för dermatologi och venereologi,Institute of Clinical Sciences, Department of Dermatology and Venereology
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Camacho, F. (author)
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(creator_code:org_t)
- 2016-10-06
- 2017
- English.
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In: Journal of the European Academy of Dermatology and Venereology. - : Wiley. - 0926-9959. ; 31:3, s. 550-556
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Abstract
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- BackgroundAlopecia areata totalis (AAT) and universalis (AAU) pose a therapeutic challenge. ObjectiveTo describe the clinical and epidemiological features, therapeutic response and prognostic factors in a large series of patients diagnosed with AAT and AAU. MethodsThis retrospective multicenter study included patients diagnosed with AAT/AAU with a minimum follow-up of 12 months. Response was assessed based on the regrowth of scalp hair. ResultsIn all, 132 patients (92 women and 40 men) - 80 (61%) diagnosed with AAU and 52 (39%) diagnosed with AAT - were included. The median time between the presentation of alopecia areata (AA) and the development of extensive AA was 1 year and it was less than 4 years in 121 patients (91%). There was an initial response to treatment in 64% of patients, although only 14% presented a persistent response. Adverse side effects from the medications used were detected in 33% of patients. The prognostic factors associated with poor response were the presence of AAU and a positive family history of AA. ConclusionsTreatment of AAT and AAU is challenging. Although an initial regrowth may be achieved, the duration of response is usually short. There were no significant differences on the effectiveness or duration of response between the various systemic therapies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Keyword
- pulse methylprednisolone therapy
- term-follow-up
- corticosteroid-therapy
- systemic corticosteroids
- oral corticosteroids
- efficacy
- update
- combination
- experience
- methotrexate
- Dermatology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Vano-Galvan, S.
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Fernandez-Crehue ...
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Grimalt, R.
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Garcia-Hernandez ...
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Rodrigues-Barata ...
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Arias-Santiago, ...
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show more...
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Molina-Ruiz, A.
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Garcia-Lora, E.
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Dominguez-Cruz, ...
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Brugues, A.
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Ferrando, J.
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Serrano-Falcon, ...
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Serrano, S.
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Paoli, John, 197 ...
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Camacho, F.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dermatology and ...
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Journal of the E ...
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University of Gothenburg