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Baseline collateral status and infarct topography in post-ischaemic perilesional hyperperfusion: An arterial spin labelling study

Bhaskar, S. (author)
Bivard, A. (author)
Stanwell, P. (author)
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Parsons, M. (author)
Attia, J. R. (author)
Nilsson, Michael, 1962 (author)
Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
Levi, C. (author)
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 (creator_code:org_t)
2016-07-21
2017
English.
In: Journal of Cerebral Blood Flow and Metabolism. - : SAGE Publications. - 0271-678X .- 1559-7016. ; 37:3, s. 1148-1162
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Focal hyperperfusion after acute ischaemic stroke could be of prognostic value depending upon its spatial localisation and temporal dynamics. Factors associated with late stage (12-24h) perilesional hyperperfusion, identified using arterial spin labelling, are poorly defined. A prospective cohort of acute ischaemic stroke patients presenting within 4.5h of symptom onset were assessed with multi-modal computed tomography acutely and magnetic resonance imaging at 24 +/- 8h. Multivariate logistic regression analysis and receiver operating characteristics curves were used. One hundred and nineteen hemispheric acute ischaemic stroke patients (mean age=71 +/- 12 years) with 24h arterial spin labelling imaging were included. Forty-two (35.3%) patients showed perilesional hyperperfusion on arterial spin labelling at 24h. Several factors were independently associated with perilesional hyperperfusion: good collaterals (71% versus 29%, P < 0.0001; OR=5, 95% CI=[1.6, 15.7], P=0.005), major reperfusion (81% versus 48%, P=< 0.0001; OR=7.5, 95% CI=[1.6, 35.1], P=0.01), penumbral salvage (76.2% versus 47%, P=0.002; OR=6.6, 95% CI=[1.8, 24.5], P=0.004), infarction in striatocapsular (OR=9.5, 95% CI=[2.6, 34], P=0.001) and in cortical superior division middle cerebral artery (OR=4.7, 95% CI=[1.4, 15.7], P=0.012) territory. The area under the receiver operating characteristic curve was 0.91. Our results demonstrate good arterial collaterals, major reperfusion, penumbral salvage, and infarct topographies involving cortical superior middle cerebral artery and striatocapsular are associated with perilesional hyperperfusion.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Keyword

Stroke
perfusion imaging
arterial spin labelling
hyperperfusion
collaterals
topography
acute ischemic-stroke
spectacular shrinking deficit
perfusion
computed-tomography
cerebral-blood-flow
hemorrhagic transformation
ct
angiography
striatocapsular infarction
tissue
brain
reperfusion
Endocrinology & Metabolism
Hematology
Neurosciences & Neurology

Publication and Content Type

ref (subject category)
art (subject category)

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