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A genetic associati...
A genetic association study of CSMD1 and CSMD2 with cognitive function
- Article/chapterEnglish2017
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LIBRIS-ID:oai:gup.ub.gu.se/253377
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https://gup.ub.gu.se/publication/253377URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133700URI
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https://doi.org/10.1016/j.bbi.2016.11.026DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-142465URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135393106URI
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The complement cascade plays a role in synaptic pruning and synaptic plasticity, which seem to be involved in cognitive functions and psychiatric disorders. Genetic variants in the closely related CSMD1 and CSMD2 genes, which are implicated in complement regulation, are associated with schizophrenia. Since patients with schizophrenia often show cognitive impairments, we tested whether variants in CSMD1 and CSMD2 are also associated with cognitive functions per se. We took a discovery-replication approach, using well-characterized Scandinavian cohorts. A total of 1637 SNPs in CSMD1 and 206 SNPs in CSMD2 were tested for association with cognitive functions in the NCNG sample (Norwegian Cognitive NeuroGenetics; n = 670). Replication testing of SNPs with p-value < 0.001 (7 in CSMD1 and 3 in CSMD2) was carried out in the TOP sample (Thematically Organized Psychosis; n =1025) and the BETULA sample (Betula Longitudinal Study on aging, memory and dementia; n = 1742). Finally, we conducted a meta-analysis of these SNPs using all three samples. The previously identified schizophrenia marker in CSMD1 (SNP rs10503253) was also included. The strongest association was observed between the CSMDI SNP rs2740931 and performance in immediate episodic memory (p-value = 5 Chi 10(-6), minor allele A, MAF 0.48-0.49, negative direction of effect). This association reached the study-wide significance level (p <= 1.2 Chi 10(-5)). SNP rs10503253 was not significantly associated with cognitive functions in our samples. In conclusion, we studied n = 3437 individuals and found evidence that a variant in CSMD1 is associated with cognitive function. Additional studies of larger samples with cognitive phenotypes will be needed to further clarify the role of CSMD1 in cognitive phenotypes in health and disease. (C) 2016 The Authors. Published by Elsevier Inc.
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Giddaluru, S.
(author)
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Fernandes, C.
(author)
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Christoforou, A.
(author)
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Reinvang, I.
(author)
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Lundervold, A. J.
(author)
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Nilsson, Lars-GöranStockholms universitet,Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden(Swepub:su)lgn
(author)
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Kauppi, KarolinaUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)kaakai04
(author)
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Adolfsson, RolfUmeå universitet,Psykiatri(Swepub:umu)road0001
(author)
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Eriksson, Elias,1956Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology(Swepub:gu)xereli
(author)
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Sundet, K.
(author)
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Djurovic, S.
(author)
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Espeseth, T.
(author)
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Nyberg, LarsUmeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för integrativ medicinsk biologi (IMB),Institutionen för strålningsvetenskaper(Swepub:umu)lany0001
(author)
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Steen, V. M.
(author)
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Andreassen, O. A.
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Le Hellard, S.
(author)
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Umeå universitetUmeå centrum för funktionell hjärnavbildning (UFBI)
(creator_code:org_t)
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In:Brain Behavior and Immunity: Elsevier BV61, s. 209-2160889-15911090-2139
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Athanasiu, L.
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Giddaluru, S.
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Fernandes, C.
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Christoforou, A.
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Reinvang, I.
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Lundervold, A. J ...
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Nilsson, Lars-Gö ...
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Kauppi, Karolina
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Adolfsson, Rolf
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Eriksson, Elias, ...
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Sundet, K.
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Djurovic, S.
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Espeseth, T.
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Nyberg, Lars
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Steen, V. M.
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Andreassen, O. A ...
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Le Hellard, S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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MEDICAL AND HEAL ...
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University of Gothenburg
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Umeå University
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Stockholm University
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Karolinska Institutet