Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity

ObjectiveAbdominal fat accumulation after menopause is associated with low-grade inflammation and increased risk of metabolic disorders. Effective long-term lifestyle treatment is therefore needed. MethodsSeventy healthy postmenopausal women (age 605.6 years) with BMI 32.55.5 were randomized to a Paleolithic-type diet (PD) or a prudent control diet (CD) for 24 months. Blood samples and fat biopsies were collected at baseline, 6 months, and 24 months to analyze inflammation-related parameters. ResultsAndroid fat decreased significantly more in the PD group (P=0.009) during the first 6 months with weight maintenance at 24 months in both groups. Long-term significant effects (P<0.001) on adipose gene expression were found for toll-like receptor 4 (decreased at 24 months) and macrophage migration inhibitory factor (increased at 24 months) in both groups. Serum interleukin 6 (IL-6) and tumor necrosis factor levels were decreased at 24 months in both groups (P<0.001) with a significant diet-by-time interaction for serum IL-6 (P=0.022). High-sensitivity C-reactive protein was decreased in the PD group at 24 months (P=0.001). ConclusionsA reduction of abdominal obesity in postmenopausal women is linked to specific changes in inflammation-related adipose gene expression.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Näringslära hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nutrition and Dietetics hsv//eng
paleolithic-type diet
adipose-tissue
weight-loss
insulin-resistance
metabolic syndrome
randomized-trial
glucose-tolerance
mononuclear-cells
messenger-rna
life-style
Endocrinology & Metabolism
Nutrition & Dietetics

Alvehus, MalinUmeå universitet,Medicin(Swepub:umu)manals98 (author)
Burén, JonasUmeå universitet,Medicin(Swepub:umu)jobu0003 (author)
Ryberg, MatsUmeå universitet,Medicin(Swepub:umu)mary0013 (author)
Larsson, Christel,1972Gothenburg University,Göteborgs universitet,Institutionen för kost- och idrottsvetenskap,Department of Food and Nutrition, and Sport Science,Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden.(Swepub:gu)xlachr (author)
Lindahl, BerntUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)beli0020 (author)
Mellberg, CarolineUmeå universitet,Medicin(Swepub:umu)caemeg00 (author)
Söderström, IngegerdUmeå universitet,Medicin(Swepub:umu)inso0001 (author)
Chorell, ElinUmeå universitet,Medicin(Swepub:umu)elnpon01 (author)
Olsson, TommyUmeå universitet,Medicin(Swepub:umu)tool0003 (author)
Umeå universitetMedicin (creator_code:org_t)

By the author/editor: Blomquist, Carol ...; Alvehus, Malin; Burén, Jonas; Ryberg, Mats; Larsson, Christe ...; Lindahl, Bernt; show more...; Mellberg, Caroli ...; Söderström, Inge ...; Chorell, Elin; Olsson, Tommy; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Endocrinology an ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

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