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The Immune Response...
The Immune Response of the Human Brain to Abdominal Surgery
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- Forsberg, A. (author)
- Karolinska Institutet
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- Cervenka, Simon (author)
- Karolinska Institutet
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- Fagerlund, M. J. (author)
- Karolinska Institutet
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- Rasmussen, L. S. (author)
- Univ Copenhagen, Rigshosp, Ctr Head & Orthoped, Dept Anesthesia, Copenhagen, Denmark.
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden.;Sahlgrenska Univ Hosp Gothenburg, Clin Neurochem Lab, Molndal, Sweden.;UCL, Inst Neurol, Dept Mol Neurosci, London, England.
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- Harris, H. E. (author)
- Karolinska Institutet
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- Stridh, P. (author)
- Karolinska Institutet
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- Christensson, E. (author)
- Karolinska Institutet
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- Granstrom, A. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, Sect Anesthesiol & Intens Care Med, Stockholm, Sweden.;Karolinska Univ Hosp, Perioperat Med & Intens Care, Stockholm, Sweden.
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- Schening, A. (author)
- Karolinska Institutet
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- Dymmel, K. (author)
- Karolinska Institutet
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- Knave, N. (author)
- Karolinska Institutet
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- Terrando, N. (author)
- Duke Univ, Med Ctr, Dept Anesthesiol, Div Basic Sci, Durham, NC 27710 USA.
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Maze, M. (author)
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- Borg, J. (author)
- Karolinska Institutet
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- Varrone, A. (author)
- Karolinska Institutet
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- Halldin, C. (author)
- Karolinska Institutet
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Molndal, Sweden.;Sahlgrenska Univ Hosp Gothenburg, Clin Neurochem Lab, Molndal, Sweden.
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- Farde, L. (author)
- Karolinska Institutet
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- Eriksson, L. I. (author)
- Karolinska Institutet
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Karolinska Institutet Univ Copenhagen, Rigshosp, Ctr Head & Orthoped, Dept Anesthesia, Copenhagen, Denmark (creator_code:org_t)
- 2017-04-11
- 2017
- English.
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In: Annals of Neurology. - : Wiley. - 0364-5134 .- 1531-8249. ; 81:4, s. 572-582
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Abstract
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- Objective: Surgery launches a systemic inflammatory reaction that reaches the brain and associates with immune activation and cognitive decline. Although preclinical studies have in part described this systemic-to-brain signaling pathway, we lack information on how these changes appear in humans. This study examines the short-and long-term impact of abdominal surgery on the human brain immune system by positron emission tomography (PET) in relation to blood immune reactivity, plasma inflammatory biomarkers, and cognitive function. Methods: Eight males undergoing prostatectomy under general anesthesia were included. Prior to surgery (baseline), at postoperative days 3 to 4, and after 3 months, patients were examined using [C-11]PBR28 brain PET imaging to assess brain immune cell activation. Concurrently, systemic inflammatory biomarkers, ex vivo blood tests on immunoreactivity to lipopolysaccharide (LPS) stimulation, and cognitive function were assessed. Results: Patients showed a global downregulation of gray matter [C-11]PBR28 binding of 26 +/- 26% (mean +/- standard deviation) at 3 to 4 days postoperatively compared to baseline (p=0.023), recovering or even increasing after 3 months. LPS-induced release of the proinflammatory marker tumor necrosis factor-a in blood displayed a reduction (41 +/- 39%) on the 3rd to 4th postoperative day, corresponding to changes in [C-11]PBR28 distribution volume. Change in Stroop Color-Word Test performance between postoperative days 3 to 4 and 3 months correlated to change in [C-11]PBR28 binding (p=0.027). Interpretation: This study translates preclinical data on changes in the brain immune system after surgery to humans, and suggests an interplay between the human brain and the inflammatory response of the peripheral innate immune system. These findings may be related to postsurgical impairments of cognitive function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- positron-emission-tomography
- postoperative cognitive dysfunction
- protein 18 kda
- vivo radioligand binding
- in-vivo
- translocator protein
- cerebrospinal-fluid
- microglial activation
- benzodiazepine-receptors
- neurofilament light
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Forsberg, A.
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Cervenka, Simon
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Fagerlund, M. J.
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Rasmussen, L. S.
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Zetterberg, Henr ...
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Harris, H. E.
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show more...
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Stridh, P.
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Christensson, E.
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Granstrom, A.
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Schening, A.
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Dymmel, K.
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Knave, N.
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Terrando, N.
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Maze, M.
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Borg, J.
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Varrone, A.
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Halldin, C.
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Blennow, Kaj, 19 ...
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Farde, L.
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Eriksson, L. I.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Annals of Neurol ...
- By the university
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University of Gothenburg
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Uppsala University
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Karolinska Institutet