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Cultured rat and pu...
Cultured rat and purified human Pneumocystis carinii stimulate intra- but not extracellular free radical production in human neutrophils.
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Jensen, T (author)
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Aliouat, E M (author)
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Lundgren, B (author)
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Settnes, O P (author)
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- Karlsson, Anna, 1967 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Dahlgren, Claes, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicinsk mikrobiologi och immunologi,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Medical Microbiology/Immunology,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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Dei-Cas, E (author)
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Obel, N (author)
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(creator_code:org_t)
- 1998
- 1998
- English.
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In: The Journal of eukaryotic microbiology. - 1066-5234. ; 45:5, s. 544-7
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Abstract
Subject headings
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- The production of free radicals in human neutrophils was studied in both Pneumocystis carinii derived from cultures of L2 rat lung epithelial-like cells and Pneumocystis carinii purified from human lung. Using the cytochrome C technique, which selectively measured extracellular superoxide generation, hardly any free radical production was observed after stimulation with cultured rat-derived P. carinii. A chemiluminescence technique, which separately measured intra- and extracellular free radical production, was subsequently employed to differentiate the free radical generation. It was established that 1) P. carinii stimulated intra- but not extracellular free radical production in human neutrophils, 2) opsonized cultured rat-derived P. carinii stimulated human neutrophils to a strong intracellular response of superoxide production, and 3) opsonized P. carinii, purified from human lung also stimulated human neutrophils to produce intracellular free radicals.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Animals
- Cell Line
- Free Radicals
- blood
- Humans
- In Vitro Techniques
- Kinetics
- Lung
- microbiology
- Neutrophils
- drug effects
- microbiology
- physiology
- Pneumocystis
- growth & development
- isolation & purification
- physiology
- Pneumonia
- Pneumocystis
- microbiology
- Rats
- Superoxides
- blood
- Tetradecanoylphorbol Acetate
- pharmacology
- Time Factors
- Zymosan
- pharmacology
Publication and Content Type
- ref (subject category)
- art (subject category)
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Jensen, T
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Aliouat, E M
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Lundgren, B
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Settnes, O P
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Karlsson, Anna, ...
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Dahlgren, Claes, ...
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show more...
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Dei-Cas, E
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Obel, N
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show less...
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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University of Gothenburg