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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005543naa a2200733 4500
001oai:gup.ub.gu.se/255014
003SwePub
008240910s2017 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2550142 URI
0247 a https://doi.org/10.1016/j.numecd.2017.03.0032 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Matikainen, N.4 aut
2451 0a Fructose intervention for 12 weeks does not impair glycemic control or incretin hormone responses during oral glucose or mixed meal tests in obese men
264 1b Elsevier BV,c 2017
520 a Background and aims: Incretin hormones glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP) are affected early on in the pathogenesis of metabolic syndrome and type 2 diabetes. Epidemiologic studies consistently link high fructose consumption to insulin resistance but whether fructose consumption impairs the incretin response remains unknown. Methods and results: As many as 66 obese (BMI 26-40 kg/m(2)) male subjects consumed fructose-sweetened beverages containing 75 g fructose/day for 12 weeks while continuing their usual lifestyle. Glucose, insulin, GLP-1 and GIP were measured during oral glucose tolerance test (OGTT) and triglycerides (TG), GLP-1, GIP and PYY during a mixed meal test before and after fructose intervention. Fructose intervention did not worsen glucose and insulin responses during OGTT, and GLP-1 and GIP responses during OGTT and fat-rich meal were unchanged. Postprandial TG response increased significantly, p = 0.004, and we observed small but significant increases in weight and liver fat content, but not in visceral or subcutaneous fat depots. However, even the subgroups who gained weight or liver fat during fructose intervention did not worsen their glucose, insulin, GLP-1 or PYY responses. A minor increase in GIP response during OGTT occurred in subjects who gained liver fat (p = 0.049). Conclusion: In obese males with features of metabolic syndrome, 12 weeks fructose intervention 75 g/day did not change glucose, insulin, GLP-1 or GIP responses during OGTT or GLP-1, GIP or PYY responses during a mixed meal. Therefore, fructose intake, even accompanied with mild weight gain, increases in liver fat and worsening of postprandial TG profile, does not impair glucose tolerance or gut incretin response to oral glucose or mixed meal challenge. (C) 2017 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a Glucagon-like peptide 1
653 a Glucose-dependent insulinotropic polypeptide
653 a Fructose intervention
653 a insulin sensitivity
653 a sweetened beverages
653 a visceral fat
653 a corn syrup
653 a intrahepatic lipids
653 a diabetes-mellitus
653 a liver fat
653 a consumption
653 a humans
653 a sucrose
653 a Cardiovascular System & Cardiology
653 a Endocrinology & Metabolism
653 a Nutrition & Dietetics
7001 a Soderlund, S.4 aut
7001 a Björnson, Elias,d 1988u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberg Laboratory,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xbelia
7001 a Bogl, L. H.4 aut
7001 a Pietilainen, K. H.4 aut
7001 a Hakkarainen, A.4 aut
7001 a Lundbom, N.4 aut
7001 a Eliasson, Björn,d 1959u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xelibj
7001 a Rasanen, S. M.4 aut
7001 a Rivellese, A.4 aut
7001 a Patti, L.4 aut
7001 a Prinster, A.4 aut
7001 a Riccardi, G.4 aut
7001 a Despres, J. P.4 aut
7001 a Almeras, N.4 aut
7001 a Holst, J. J.4 aut
7001 a Deacon, C. F.4 aut
7001 a Boren, J.4 aut
7001 a Taskinen, M. R.4 aut
7102 a Göteborgs universitetb Wallenberglaboratoriet4 org
7730 t Nutrition Metabolism and Cardiovascular Diseasesd : Elsevier BVg 27:6, s. 534-542q 27:6<534-542x 0939-4753
8564 u https://helda.helsinki.fi/bitstream/10138/237043/1/Fructose_intervention.pdf
8564 8u https://gup.ub.gu.se/publication/255014
8564 8u https://doi.org/10.1016/j.numecd.2017.03.003

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