Phosphorylation and negative regulation of CONSTITUTIVELY PHOTOMORPHOGENIC 1 by PINOID in Arabidopsis

CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays crucial roles in various cellular processes via its E3 ubiquitin ligase activity in organisms, ranging from fungi to humans. As a key component in regulating various biological events, COP1 itself is precisely controlled at multiple layers. Here, we report a negative regulator of COP1, PINOID (PID), which positively mediates photomorphogenic development. Specifically, PID genetically and physically interacts with COP1 and directly phosphorylates COP1 at Ser20. As a result, this posttranslational modification serves to repress COP1 activity and promote photomorphogenesis. Our findings signify a key regulatory mechanism for precisely maintaining COP1 activity, thereby ensuring appropriate development in plants.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
Arabidopsis
photomorphogenesis
phosphorylation
PID
COP1
UBIQUITIN LIGASE COP1
B-BOX PROTEIN
TUMOR-SUPPRESSOR
GENE-EXPRESSION
E3 LIGASE
MEDIATED DEGRADATION
AUXIN TRANSPORT
DNA-DAMAGE
PHYTOCHROME
PHOTORECEPTORS

Xu, D. Q. (author)
Jiang, Y. (author)
Chen, H. D. (author)
Fan, L. M. (author)
Holm, Magnus,1968Gothenburg University,Göteborgs universitet,Institutionen för biologi och miljövetenskap,Department of Biological and Environmental Sciences(Swepub:gu)xhomag (author)
Deng, X. W. (author)
Göteborgs universitetInstitutionen för biologi och miljövetenskap (creator_code:org_t)

In:Proceedings of the National Academy of Sciences of the United States of America: Proceedings of the National Academy of Sciences114:25, s. 6617-66220027-8424
In:Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences114:25, s. 6617-66221091-6490

By the author/editor: Lin, F.; Xu, D. Q.; Jiang, Y.; Chen, H. D.; Fan, L. M.; Holm, Magnus, 19 ...; show more...; Deng, X. W.; show less...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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