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  • Chorell, ElinUmeå universitet,Umeå University,Medicin (author)

Pregnancy to postpartum transition of serum metabolites in women with gestational diabetes

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elsevier BV,2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/255418
  • https://gup.ub.gu.se/publication/255418URI
  • https://doi.org/10.1016/j.metabol.2016.12.018DOI
  • https://lup.lub.lu.se/record/5c0a51a1-8164-4d51-9871-559f2a81b7eaURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137792URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Context. Gestational diabetes is commonly linked to development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with gestational diabetes in order to find novel biomarkers for T2DM. Objective. To find potential pathophysiological mechanisms and markers for progression from gestational diabetes mellitus to T2DM by studying the metabolic transition from pregnancy to postpartum. Design. The metabolic transition profile from pregnancy to postpartum was characterized in 56 women by mass spectrometry-based metabolomics; 11 women had gestational diabetes mellitus, 24 had normal glucose tolerance, and 21 were normoglycaemic but at increased risk for gestational diabetes mellitus. Fasting serum samples collected during trimester 3 (gestational week 32 +/- 0.6) and postpartum (10.5 +/- 0.4 months) were compared in diagnosis-specific multivariate models (orthogonal partial least squares analysis). Clinical measurements (e.g., insulin, glucose, lipid levels) were compared and models of insulin sensitivity and resistance were calculated for the same time period. Results. Women with gestational diabetes had significantly increased postpartum levels of the branched-chain amino acids (BCAAs) leucine, isoleucine, and valine, and their circulating lipids did not return to normal levels after pregnancy. The increase in BCAAs occurred postpartum since the BCAAs did not differ during pregnancy, as compared to normoglycemic women. Conclusions. Postpartum levels of specific BCAAs, notably valine, are related to gestational diabetes during pregnancy. (C) 2017 Elsevier Inc. All rights reserved.

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  • Hall, Ulrika AnderssonUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xaulri (author)
  • Gustavsson, CarolinaUniversity of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xgucar (author)
  • Berntorp, KerstinLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-kbe (author)
  • Puhkala, J.UKK Institute for Health Promotion Research,Finnish National Institute for Health and Welfare (author)
  • Luoto, R.UKK Institute for Health Promotion Research,Finnish National Institute for Health and Welfare (author)
  • Olsson, TommyUmeå universitet,Umeå University,Medicin(Swepub:umu)tool0003 (author)
  • Holmäng, Agneta,1959University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology(Swepub:gu)xholag (author)
  • Umeå UniversityMedicin (creator_code:org_t)

Related titles

  • In:Metabolism-Clinical and Experimental: Elsevier BV72, s. 27-360026-04951532-8600

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