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MBOAT7 rs641738 var...
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
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Donati, B. (author)
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Dongiovanni, P. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Meroni, M. (author)
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McCain, M. (author)
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Miele, L. (author)
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Petta, S. (author)
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Maier, S. (author)
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Rosso, C. (author)
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De Luca, L. (author)
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Vanni, E. (author)
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Grimaudo, S. (author)
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Romagnoli, R. (author)
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Colli, F. (author)
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Ferri, F. (author)
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- Mancina, Rosellina Margherita (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Iruzubieta, P. (author)
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Craxi, A. (author)
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Fracanzani, A. L. (author)
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Grieco, A. (author)
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Corradini, S. G. (author)
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Aghemo, A. (author)
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Colombo, M. (author)
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Soardo, G. (author)
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Bugianesi, E. (author)
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Reeves, H. (author)
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Anstee, Q. M. (author)
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Fargion, S. (author)
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Valenti, L. (author)
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(creator_code:org_t)
- 2017-07-03
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1
- Related links:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08-2.55; n = 765), particularly in those without advanced fibrosis (p < 0.001). The risk T allele was linked to 3'-UTR variation in MBOAT7 and to reduced MBOAT7 expression in patients without severe fibrosis. The number of PNPLA3, TM6SF2, and MBOAT7 risk variants was associated with NAFLD-HCC independently of clinical factors (p < 0.001), but did not significantly improve their predictive accuracy. When combining data from an independent UK NAFLD cohort, in the overall cohort of non-cirrhotic patients (n = 913, 41 with HCC) the T allele remained associated with HCC (OR 2.10, 1.33-3.31). Finally, in a combined cohort of non-cirrhotic patients with chronic hepatitis C or alcoholic liver disease (n = 1121), the T allele was independently associated with HCC risk (OR 1.93, 1.07-3.58). In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- fatty liver-disease
- chronic hepatitis-c
- nonalcoholic steatohepatitis
- confers susceptibility
- i148m polymorphism
- wide association
- pnpla3
- rs738409
- fibrosis
- risk
- tm6sf2
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Donati, B.
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Dongiovanni, P.
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Romeo, Stefano, ...
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Meroni, M.
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McCain, M.
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Miele, L.
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show more...
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Petta, S.
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Maier, S.
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Rosso, C.
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De Luca, L.
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Vanni, E.
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Grimaudo, S.
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Romagnoli, R.
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Colli, F.
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Ferri, F.
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Mancina, Roselli ...
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Iruzubieta, P.
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Craxi, A.
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Fracanzani, A. L ...
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Grieco, A.
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Corradini, S. G.
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Aghemo, A.
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Colombo, M.
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Soardo, G.
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Bugianesi, E.
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Reeves, H.
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Anstee, Q. M.
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Fargion, S.
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Valenti, L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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Scientific Repor ...
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University of Gothenburg