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MBOAT7 rs641738 var...
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-07-03
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Springer Science and Business Media LLC,2017
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LIBRIS-ID:oai:gup.ub.gu.se/255480
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https://gup.ub.gu.se/publication/255480URI
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https://doi.org/10.1038/s41598-017-04991-0DOI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Nonalcoholic fatty liver disease (NAFLD) represents an emerging cause of hepatocellular carcinoma (HCC), especially in non-cirrhotic individuals. The rs641738 C > T MBOAT7/TMC4 variant predisposes to progressive NAFLD, but the impact on hepatic carcinogenesis is unknown. In Italian NAFLD patients, the rs641738 T allele was associated with NAFLD-HCC (OR 1.65, 1.08-2.55; n = 765), particularly in those without advanced fibrosis (p < 0.001). The risk T allele was linked to 3'-UTR variation in MBOAT7 and to reduced MBOAT7 expression in patients without severe fibrosis. The number of PNPLA3, TM6SF2, and MBOAT7 risk variants was associated with NAFLD-HCC independently of clinical factors (p < 0.001), but did not significantly improve their predictive accuracy. When combining data from an independent UK NAFLD cohort, in the overall cohort of non-cirrhotic patients (n = 913, 41 with HCC) the T allele remained associated with HCC (OR 2.10, 1.33-3.31). Finally, in a combined cohort of non-cirrhotic patients with chronic hepatitis C or alcoholic liver disease (n = 1121), the T allele was independently associated with HCC risk (OR 1.93, 1.07-3.58). In conclusion, the MBOAT7 rs641738 T allele is associated with reduced MBOAT7 expression and may predispose to HCC in patients without cirrhosis, suggesting it should be evaluated in future prospective studies aimed at stratifying NAFLD-HCC risk.
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Dongiovanni, P.
(author)
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Romeo, Stefano,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xroste
(author)
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Meroni, M.
(author)
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McCain, M.
(author)
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Miele, L.
(author)
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Petta, S.
(author)
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Maier, S.
(author)
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Rosso, C.
(author)
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De Luca, L.
(author)
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Vanni, E.
(author)
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Grimaudo, S.
(author)
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Romagnoli, R.
(author)
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Colli, F.
(author)
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Ferri, F.
(author)
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Mancina, Rosellina MargheritaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xmanro
(author)
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Iruzubieta, P.
(author)
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Craxi, A.
(author)
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Fracanzani, A. L.
(author)
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Grieco, A.
(author)
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Corradini, S. G.
(author)
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Aghemo, A.
(author)
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Colombo, M.
(author)
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Soardo, G.
(author)
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Bugianesi, E.
(author)
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Reeves, H.
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Anstee, Q. M.
(author)
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Fargion, S.
(author)
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Valenti, L.
(author)
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Göteborgs universitetInstitutionen för medicin, avdelningen för molekylär och klinisk medicin
(creator_code:org_t)
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In:Scientific Reports: Springer Science and Business Media LLC7:12045-2322
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Donati, B.
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Dongiovanni, P.
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Romeo, Stefano, ...
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Meroni, M.
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McCain, M.
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Miele, L.
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Petta, S.
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Maier, S.
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Rosso, C.
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De Luca, L.
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Vanni, E.
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Grimaudo, S.
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Romagnoli, R.
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Colli, F.
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Ferri, F.
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Mancina, Roselli ...
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Iruzubieta, P.
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Craxi, A.
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Fracanzani, A. L ...
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Grieco, A.
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Corradini, S. G.
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Aghemo, A.
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Colombo, M.
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Soardo, G.
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Bugianesi, E.
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Reeves, H.
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Anstee, Q. M.
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Fargion, S.
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Valenti, L.
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