Search: onr:"swepub:oai:gup.ub.gu.se/255982" >
Alzheimer's disease...
Alzheimer's disease markers in the aged sheep (Ovis aries).
-
Reid, Suzanne J (author)
-
Mckean, Natasha E (author)
-
Henty, Kristen (author)
-
show more...
-
- Portelius, Erik, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Rudiger, Skye R (author)
-
Bawden, C Simon (author)
-
Handley, Renee R (author)
-
Verma, Paul J (author)
-
Faull, Richard L M (author)
-
Waldvogel, Henry J (author)
-
- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
-
Snell, Russell G (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
-
In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 58, s. 112-119
- Related links:
-
https://discovery.uc...
-
show more...
-
https://gup.ub.gu.se...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- This study reports the identification and characterization of markers of Alzheimer's disease (AD) in aged sheep (Ovis aries) as a preliminary step toward making a genetically modified large animal model of AD. Importantly, the sequences of key proteins involved in AD pathogenesis are highly conserved between sheep and human. The processing of the amyloid-β (Aβ) protein is conserved between sheep and human, and sheep Aβ1-42/Aβ1-40 ratios in cerebrospinal fluid (CSF) are also very similar to human. In addition, total tau and neurofilament light levels in CSF are comparable with those found in human. The presence of neurofibrillary tangles in aged sheep brain has previously been established; here, we report for the first time that plaques, the other pathologic hallmark of AD, are also present in the aged sheep brain. In summary, the biological machinery to generate the key neuropathologic features of AD is conserved between the human and sheep, making the sheep a good candidate for future genetic manipulation to accelerate the condition for use in pathophysiological discovery and therapeutic testing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Reid, Suzanne J
-
Mckean, Natasha ...
-
Henty, Kristen
-
Portelius, Erik, ...
-
Blennow, Kaj, 19 ...
-
Rudiger, Skye R
-
show more...
-
Bawden, C Simon
-
Handley, Renee R
-
Verma, Paul J
-
Faull, Richard L ...
-
Waldvogel, Henry ...
-
Zetterberg, Henr ...
-
Snell, Russell G
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Neurobiology of ...
- By the university
-
University of Gothenburg