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Mycophenolate mofet...
Mycophenolate mofetil ameliorates perivascular T lymphocyte inflammation and reduces the double-negative T cell population in SLE-prone MRLlpr/lpr mice.
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- Jonsson, Charlotte A, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Erlandsson, Malin, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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- Svensson, Lena, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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Mölne, J (author)
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- Carlsten, Hans, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning,Institute of Internal Medicine, Dept of Rheumatology and Inflammation Research
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(creator_code:org_t)
- Elsevier BV, 1999
- 1999
- English.
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In: Cellular immunology. - : Elsevier BV. - 0008-8749. ; 197:2, s. 136-44
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Effects on T lymphocyte mediated pathology, phenotypes, and functions in MRLlpr/lpr mice given mycophenolate mofetil (MMF) (100 mg/kg/day) via drinking water or controls given ip cyclophosphamide (CYC) injections (1.8 mg/mouse/week) or water were described. Both MMF and CYC treatment diminished kidney and large salivary gland perivascular cell infiltrates, reduced profoundly double-negative (DN) T cell frequencies, decreased total lymphocyte number in spleen, and increased in vitro proliferative response to Con A. IFN-gamma and IL-10 in supernatants from Con A stimulated spleen cells were augmented after MMF but not CYC treatment. MMF treatment increased whereas CYC reduced IL-12 in serum. Kidney expressions of IFN-gamma, IL-10, and IL-12 mRNA were unaffected by MMF but decreased by CYC. Our results demonstrate that MMF and CYC suppress perivascular T lymphocyte inflammation by reducing the DN T cell population and by amelioration of T cell function. The varying cytokine patterns suggest different mechanisms of the two drugs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Animals
- Anti-Inflammatory Agents
- Non-Steroidal
- pharmacology
- B-Lymphocytes
- drug effects
- immunology
- Cell Count
- Cell Division
- Concanavalin A
- pharmacology
- Cyclophosphamide
- pharmacology
- Cytokines
- blood
- genetics
- Disease Models
- Animal
- Female
- Hypersensitivity
- Delayed
- Immunophenotyping
- Immunosuppressive Agents
- pharmacology
- Kidney
- blood supply
- cytology
- immunology
- Lupus Erythematosus
- Systemic
- immunology
- Male
- Mice
- Mice
- Inbred MRL lpr
- Mycophenolic Acid
- analogs & derivatives
- pharmacology
- RNA
- Messenger
- Salivary Glands
- blood supply
- cytology
- Spleen
- cytology
- immunology
- T-Lymphocytes
- cytology
- drug effects
- immunology
- Vasculitis
- pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
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