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Prestroke CHA(2)DS(...
Prestroke CHA(2)DS(2)-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study
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Acciarresi, M. (author)
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Paciaroni, M. (author)
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Agnelli, G. (author)
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show more...
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Falocci, N. (author)
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Caso, V. (author)
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Becattini, C. (author)
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Marcheselli, S. (author)
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Rueckert, C. (author)
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Pezzini, A. (author)
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Morotti, A. (author)
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Costa, P. (author)
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Padovani, A. (author)
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Csiba, L. (author)
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Szabo, L. (author)
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Sohn, S. I. (author)
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Tassinari, T. (author)
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Abdul-Rahim, A. H. (author)
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Michel, P. (author)
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Cordier, M. (author)
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Vanacker, P. (author)
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Remillard, S. (author)
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Alberti, A. (author)
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Venti, M. (author)
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D'Amore, C. (author)
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Scoditti, U. (author)
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Denti, L. (author)
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Orlandi, G. (author)
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Chiti, A. (author)
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Gialdini, G. (author)
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Bovi, P. (author)
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Carletti, M. (author)
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Rigatelli, A. (author)
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Putaala, J. (author)
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- Tatlisumak, Turgut (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
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Masotti, L. (author)
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Lorenzini, G. (author)
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Tassi, R. (author)
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Guideri, F. (author)
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Martini, G. (author)
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Tsivgoulis, G. (author)
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Vadikolias, K. (author)
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Liantinioti, C. (author)
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Corea, F. (author)
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Del Sette, M. (author)
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Ageno, W. (author)
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De Lodovici, M. L. (author)
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Bono, G. (author)
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Baldi, A. (author)
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D'Anna, S. (author)
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Sacco, S. (author)
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Carolei, A. (author)
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Tiseo, C. (author)
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Imberti, D. (author)
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Zabzuni, D. (author)
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Doronin, B. (author)
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Volodina, V. (author)
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Consoli, D. (author)
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Galati, F. (author)
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Pieroni, A. (author)
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Toni, D. (author)
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Monaco, S. (author)
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Baronello, M. M. (author)
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Barlinn, K. (author)
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Pallesen, L. P. (author)
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Kepplinger, J. (author)
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Bodechtel, U. (author)
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Gerber, J. (author)
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Deleu, D. (author)
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Melikyan, G. (author)
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Ibrahim, F. (author)
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Akhtar, N. (author)
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Mosconi, M. G. (author)
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Lees, K. R. (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Journal of Stroke & Cerebrovascular Diseases. - : Elsevier BV. - 1052-3057. ; 26:6, s. 1363-1368
- Related links:
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https://helda.helsin...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background and Purpose: The aim of this study was to investigate for a possible association between both prestroke CHA(2)DS(2)-VASc score and the severity of stroke at presentation, as well as disability and mortality at 90 days, in patients with acute stroke and atrial fibrillation (AF). Methods: This prospective study enrolled consecutive patients with acute ischemic stroke, AF, and assessment of prestroke CHA2DS2-VASc score. Severity of stroke was assessed on admission using the National Institutes of Health Stroke Scale (NIHSS) score (severe stroke: NIHSS >= 10). Disability and mortality at 90 days were assessed by the modified Rankin Scale (mRS < 3 or >= 3). Multiple logistic regression was used to correlate prestroke CHA(2)DS(2)-VASc and severity of stroke, as well as disability and mortality at 90 days. Results: Of the 1020 patients included in the analysis, 606 patients had an admission NIHSS score lower and 414 patients higher than 10. At 90 days, 510 patients had mRS >= 3. A linear correlation was found between the prestroke CHA(2)DS(2)-VASc score and severity of stroke (P = .001). On multivariate analysis, CHA(2)DS(2)-VASc score correlated with severity of stroke (P = .041) and adverse functional outcome (mRS = 3) (P = .001). A logistic regression with the receiver operating characteristic graph procedure (C-statistics) evidenced an area under the curve of .60 (P = .0001) for severe stroke. Furthermore, a correlation was found between prestroke CHA(2)DS(2)-VASc score and lesion size. Conclusions: In patients with AF, in addition to the risk of stroke, a high CHA(2)DS(2)-VASc score was independently associated with both stroke severity at onset and disability and mortality at 90 days.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Ischemic stroke
- CHA(2)DS(2)-VASc score
- severity
- outcome
- atrial fibrillation
- scores
- acute ischemic-stroke
- arterial territories
- human brain
- outcomes
- chads(2)
- Neurosciences & Neurology
- Cardiovascular System & Cardiology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Acciarresi, M.
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Paciaroni, M.
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Agnelli, G.
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Falocci, N.
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Caso, V.
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Becattini, C.
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show more...
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Marcheselli, S.
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Rueckert, C.
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Pezzini, A.
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Morotti, A.
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Costa, P.
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Padovani, A.
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Csiba, L.
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Szabo, L.
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Sohn, S. I.
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Tassinari, T.
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Abdul-Rahim, A. ...
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Michel, P.
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Cordier, M.
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Vanacker, P.
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Remillard, S.
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Alberti, A.
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Venti, M.
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D'Amore, C.
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Scoditti, U.
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Denti, L.
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Orlandi, G.
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Chiti, A.
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Gialdini, G.
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Bovi, P.
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Carletti, M.
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Rigatelli, A.
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Putaala, J.
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Tatlisumak, Turg ...
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Masotti, L.
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Lorenzini, G.
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Tassi, R.
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Guideri, F.
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Martini, G.
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Tsivgoulis, G.
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Vadikolias, K.
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Liantinioti, C.
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Corea, F.
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Del Sette, M.
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Ageno, W.
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De Lodovici, M. ...
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Bono, G.
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Baldi, A.
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D'Anna, S.
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Sacco, S.
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Carolei, A.
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Tiseo, C.
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Imberti, D.
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Zabzuni, D.
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Doronin, B.
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Volodina, V.
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Consoli, D.
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Galati, F.
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Pieroni, A.
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Toni, D.
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Monaco, S.
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Baronello, M. M.
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Barlinn, K.
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Pallesen, L. P.
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Kepplinger, J.
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Bodechtel, U.
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Gerber, J.
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Deleu, D.
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Melikyan, G.
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Ibrahim, F.
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Akhtar, N.
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Mosconi, M. G.
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Lees, K. R.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Strok ...
- By the university
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University of Gothenburg