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  • Ermund, AnnaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology (author)

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elsevier BV,2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/258730
  • https://gup.ub.gu.se/publication/258730URI
  • https://doi.org/10.1016/j.bbrc.2017.08.113DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215783URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136694251URI

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  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20171023
  • To understand the mucociliary clearance system, mucins were visualized by light, confocal and electron microscopy, and mucus was stained by Alcian blue and tracked by video microscopy on tracheal explants of newborn piglets. We observed long linear mucus bundles that appeared at the submucosal gland openings and were transported cephalically. The mucus bundles were shown by mass spectrometry and immunostaining to have a core made of MUC5B mucin and were coated with MUC5AC mucin produced by surface goblet cells. The transport speed of the bundles was slower than the airway surface liquid flow. We suggest that the goblet cell MUC5AC mucin anchors the mucus bundles and thus controls their transport. Normal clearance of the respiratory tree of pigs and humans, both rich in submucosal glands, is performed by thick and long mucus bundles. (C) 2017 The Authors. Published by Elsevier Inc.

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  • Meiss, Lauren NGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology (author)
  • Rodríguez-Piñeiro, Ana MaríaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xrodan (author)
  • Bahr, A. (author)
  • Nilsson, Harriet E.Karolinska Institutet,KTH,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology,Medicinsk teknik,Department of Medical Biochemistry, University of Gothenburg, SE-405 30 Gothenburg, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal Institute of Technology, Novum, SE-141 57 Huddinge, Sweden(Swepub:kth)u1xjilap (author)
  • Trillo-Muyo, Sergio,1983Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xtrise (author)
  • Ridley, C. (author)
  • Thornton, D. J. (author)
  • Wine, J. J. (author)
  • Hebert, HansKTH,Strukturell bioteknik,Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal Institute of Technology, Novum, SE-141 57 Huddinge, Sweden(Swepub:kth)u1h8ygcn (author)
  • Klymiuk, N. (author)
  • Hansson, Gunnar C.,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology(Swepub:gu)xhagun (author)
  • Göteborgs universitetInstitutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (creator_code:org_t)

Related titles

  • In:Biochemical and Biophysical Research Communications - BBRC: Elsevier BV492:3, s. 331-3370006-291X1090-2104

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