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Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
- Kootte, R. S. (author)
- Levin, E. (author)
- Salojarvi, J. (author)
- show more...
- Smits, L. P. (author)
- Hartstra, A. V. (author)
- Udayappan, S. D. (author)
- Hermes, G. (author)
- Bouter, K. E. (author)
- Koopen, A. M. (author)
- Holst, J. J. (author)
- Knop, F. K. (author)
- Blaak, E. E. (author)
- Zhao, J. (author)
- Smidt, H. (author)
- Harms, A. C. (author)
- Hankemeijer, T. (author)
- Bergman, Jjghm (author)
- Romijn, H. A. (author)
- Schaap, F. G. (author)
- Damink, Swmo (author)
- Ackermans, M. T. (author)
- Dallinga-Thie, G. M. (author)
- Zoetendal, E. (author)
- de Vos, W. M. (author)
- Serlie, M. J. (author)
- Stroes, E. S. G. (author)
- Groen, A. K. (author)
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- (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
- In: Cell Metabolism. - : Elsevier BV. - 1550-4131. ; 26:4, s. 611-619
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as gamma-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- recurrent clostridium-difficile
- bile-acid metabolism
- chain
- fatty-acids
- gut microbiota
- markers
- obesity
- transplantation
- lactobacillus
- selection
- bacteria
- Cell Biology
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
- Kootte, R. S.
- Levin, E.
- Salojarvi, J.
- Smits, L. P.
- Hartstra, A. V.
- Udayappan, S. D.
- show more...
- Hermes, G.
- Bouter, K. E.
- Koopen, A. M.
- Holst, J. J.
- Knop, F. K.
- Blaak, E. E.
- Zhao, J.
- Smidt, H.
- Harms, A. C.
- Hankemeijer, T.
- Bergman, Jjghm
- Romijn, H. A.
- Schaap, F. G.
- Damink, Swmo
- Ackermans, M. T.
- Dallinga-Thie, G ...
- Zoetendal, E.
- de Vos, W. M.
- Serlie, M. J.
- Stroes, E. S. G.
- Groen, A. K.
- Nieuwdorp, Max
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Microbiology in ...
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Endocrinology an ...
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- NATURAL SCIENCES
- NATURAL SCIENCES
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- and Cell Biology
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- Cell Metabolism
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- University of Gothenburg
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