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  • Kootte, R. S. (author)

Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elsevier BV,2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/258758
  • https://gup.ub.gu.se/publication/258758URI
  • https://doi.org/10.1016/j.cmet.2017.09.008DOI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We therefore studied the effect of lean donor (allogenic) versus own (autologous) fecal microbiota transplantation (FMT) to male recipients with the metabolic syndrome. Whereas we did not observe metabolic changes at 18 weeks after FMT, insulin sensitivity at 6 weeks after allogenic FMT was significantly improved, accompanied by altered microbiota composition. We also observed changes in plasma metabolites such as gamma-aminobutyric acid and show that metabolic response upon allogenic FMT (defined as improved insulin sensitivity 6 weeks after FMT) is dependent on decreased fecal microbial diversity at baseline. In conclusion, the beneficial effects of lean donor FMT on glucose metabolism are associated with changes in intestinal microbiota and plasma metabolites and can be predicted based on baseline fecal microbiota composition.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Levin, E. (author)
  • Salojarvi, J. (author)
  • Smits, L. P. (author)
  • Hartstra, A. V. (author)
  • Udayappan, S. D. (author)
  • Hermes, G. (author)
  • Bouter, K. E. (author)
  • Koopen, A. M. (author)
  • Holst, J. J. (author)
  • Knop, F. K. (author)
  • Blaak, E. E. (author)
  • Zhao, J. (author)
  • Smidt, H. (author)
  • Harms, A. C. (author)
  • Hankemeijer, T. (author)
  • Bergman, Jjghm (author)
  • Romijn, H. A. (author)
  • Schaap, F. G. (author)
  • Damink, Swmo (author)
  • Ackermans, M. T. (author)
  • Dallinga-Thie, G. M. (author)
  • Zoetendal, E. (author)
  • de Vos, W. M. (author)
  • Serlie, M. J. (author)
  • Stroes, E. S. G. (author)
  • Groen, A. K. (author)
  • Nieuwdorp, MaxGothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory(Swepub:gu)xnieum (author)
  • Göteborgs universitetWallenberglaboratoriet (creator_code:org_t)

Related titles

  • In:Cell Metabolism: Elsevier BV26:4, s. 611-6191550-4131

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