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Automated analysis ...
Automated analysis of liver fat, muscle and adipose tissue distribution from CT suitable for large-scale studies
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- Kullberg, Joel, 1979- (author)
- Uppsala universitet,Radiologi,Antaros Med, BioVenture Hub, Molndal, Sweden
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- Hedström, Anders (author)
- Uppsala universitet,Radiologi,Antaros Med, BioVenture Hub, Molndal, Sweden
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- Brandberg, J. (author)
- Sahlgrens Univ Hosp, Dept Radiol, Gothenburg, Sweden
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- Strand, Robin, 1978- (author)
- Uppsala universitet,Radiologi
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- Johansson, Lars E (author)
- Uppsala universitet,Radiologi,Antaros Med, BioVenture Hub, Molndal, Sweden
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- Bergström, Göran, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine,Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Med, BioVenture Hub, Molndal, Sweden
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(creator_code:org_t)
- 2017-09-05
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Abstract
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- Computed Tomography (CT) allows detailed studies of body composition and its association with metabolic and cardiovascular disease. The purpose of this work was to develop and validate automated and manual image processing techniques for detailed and efficient analysis of body composition from CT data. The study comprised 107 subjects examined in the Swedish CArdioPulmonary BioImage Study (SCAPIS) using a 3-slice CT protocol covering liver, abdomen, and thighs. Algorithms were developed for automated assessment of liver attenuation, visceral (VAT) and subcutaneous (SAT) abdominal adipose tissue, thigh muscles, subcutaneous, subfascial (SFAT) and intermuscular adipose tissue. These were validated using manual reference measurements. SFAT was studied in selected subjects were the fascia lata could be visually identified (approx. 5%). In addition, precision of manual measurements of intra-(IPAT) and retroperitoneal adipose tissue (RPAT) and deep-and superficial SAT was evaluated using repeated measurements. Automated measurements correlated strongly to manual reference measurements. The SFAT depot showed the weakest correlation (r = 0.744). Automated VAT and SAT measurements were slightly, but significantly overestimated (<= 4.6%, p <= 0.001). Manual segmentation of abdominal sub-depots showed high repeatability (CV <= 8.1%, r >= 0.930). We conclude that the low dose CT-scanning and automated analysis makes the setup suitable for large-scale studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- insulin-resistance
- computed-tomography
- abdominal fat
- quantification
- segmentation
- obesity
- thigh
- mri
- accurate
- images
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kullberg, Joel, ...
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Hedström, Anders
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Brandberg, J.
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Strand, Robin, 1 ...
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Johansson, Lars ...
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Bergström, Göran ...
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Ahlström, Håkan, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg
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Uppsala University