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Association between...
Association between low C-peptide and fragility fractures in postmenopausal women without diabetes
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Ferro, Y. (author)
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Russo, C. (author)
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Russo, D. (author)
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Gazzaruso, C. (author)
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Coppola, A. (author)
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Gallotti, P. (author)
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Zambianchi, V. (author)
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Fodaro, M. (author)
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- Romeo, Stefano, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Center for Cardiovascular and Metabolic Research (CMR),Institute of Medicine, Department of Molecular and Clinical Medicine
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Galliera, E. (author)
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Marazzi, M. G. (author)
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Romanelli, M. M. C. (author)
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Giannini, S. (author)
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Pujia, A. (author)
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Montalcini, T. (author)
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(creator_code:org_t)
- 2017-04-11
- 2017
- English.
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In: Journal of Endocrinological Investigation. - : Springer Science and Business Media LLC. - 1720-8386. ; 40:10, s. 1091-1098
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Purpose C-peptide has been shown to exert several, previously unknown, biological effects. A recent cross-sectional study demonstrated an association between low C-peptide serum levels and low lumbar bone density of postmenopausal women not affected by diabetes. To date, very little research attention has been directed toward the association between C-peptide and osteoporotic fractures. To contribute toward filling this gap, we investigated the association between C-peptide and fractures in postmenopausal women. Methods A cohort of 133 non-diabetic postmenopausal women with and without a history of fractures was evaluated in this cross-sectional investigation. Standardized interviews were performed to gather information on the patients' fracture history. All of the participants underwent a bone mineral density assessment by DXA, radiographs, and a serum C-peptide measurement. Results Thirty-four women presented fractures. Bivariate analysis revealed an inverse correlation between C-peptide and fractures (r = -0.27, p = 0.002). A significant difference in mean C-peptide levels was also found between women with vs. without fractures (p = 0.01, adjusted for age, BMI and glucose). Logistic regression analysis showed that C-peptide levels, femoral and vertebral BMD were all negatively associated with fracture status (B = -1.097, ES = 0.401, p = 0.006, 95% CI 0.15-0.73; B = -15.6, SE = 4.17, p < 0.001, CI 0.001-0.002; B = -24.8, SE = 5.23, p < 0.001, CI 0001-0.002; respectively). Conclusions This study confirms an inverse association between serum C-peptide levels and a history of fractures in postmenopausal women without diabetes. These results suggest that C-peptidemay exert an effect on bone mineral density. However, further large-scale studies are needed to corroborate this finding and investigate the potential underlying mechanisms involved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Osteoporosis
- Fractures
- C-Peptide
- Postmenopausal women
- Diabetes
- bone-mineral density
- carotid atherosclerosis
- complications trial
- type-1
- osteoporosis
- risk
- calcium
- mass
- men
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ferro, Y.
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Russo, C.
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Russo, D.
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Gazzaruso, C.
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Coppola, A.
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Gallotti, P.
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show more...
-
Zambianchi, V.
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Fodaro, M.
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Romeo, Stefano, ...
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Galliera, E.
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Marazzi, M. G.
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Romanelli, M. M. ...
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Giannini, S.
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Pujia, A.
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Montalcini, T.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Journal of Endoc ...
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University of Gothenburg