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Gut microbiome alte...
Gut microbiome alterations in Alzheimer's disease
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Vogt, N. M. (author)
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Kerby, R. L. (author)
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Dill-McFarland, K. A. (author)
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Harding, S. J. (author)
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Merluzzi, A. P. (author)
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Johnson, S. C. (author)
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Carlsson, C. M. (author)
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Asthana, S. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Bendlin, B. B. (author)
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Rey, F. E. (author)
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(creator_code:org_t)
- 2017-10-19
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Alzheimer's disease (AD) is the most common form of dementia. However, the etiopathogenesis of this devastating disease is not fully understood. Recent studies in rodents suggest that alterations in the gut microbiome may contribute to amyloid deposition, yet the microbial communities associated with AD have not been characterized in humans. Towards this end, we characterized the bacterial taxonomic composition of fecal samples from participants with and without a diagnosis of dementia due to AD. Our analyses revealed that the gut microbiome of AD participants has decreased microbial diversity and is compositionally distinct from control age-and sex-matched individuals. We identified phylum-through genus-wide differences in bacterial abundance including decreased Firmicutes, increased Bacteroidetes, and decreased Bifidobacterium in the microbiome of AD participants. Furthermore, we observed correlations between levels of differentially abundant genera and cerebrospinal fluid (CSF) biomarkers of AD. These findings add AD to the growing list of diseases associated with gut microbial alterations, as well as suggest that gut bacterial communities may be a target for therapeutic intervention.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- middle-aged adults
- transgenic mice
- insulin-resistance
- intestinal
- microbiota
- cerebrospinal-fluid
- parkinsons-disease
- cognitive function
- infant gut
- health
- brain
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Vogt, N. M.
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Kerby, R. L.
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Dill-McFarland, ...
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Harding, S. J.
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Merluzzi, A. P.
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Johnson, S. C.
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show more...
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Carlsson, C. M.
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Asthana, S.
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Zetterberg, Henr ...
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Blennow, Kaj, 19 ...
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Bendlin, B. B.
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Rey, F. E.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Scientific Repor ...
- By the university
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University of Gothenburg