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Ondansetron treatme...
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Hagbom, MarieLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
(author)
Ondansetron treatment reduces rotavirus symptoms-A randomized double-blinded placebo-controlled trial
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-10-27
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Public Library of Science (PLoS),2017
Numbers
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LIBRIS-ID:oai:gup.ub.gu.se/259620
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https://gup.ub.gu.se/publication/259620URI
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https://doi.org/10.1371/journal.pone.0186824DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-142977URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136946644URI
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [320301]; Swedish Research Council
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Background Rotavirus and norovirus cause acute gastroenteritis with severe diarrhoea and vomiting, symptoms that may lead to severe dehydration and death. The objective of this randomized double-blinded placebo-controlled study was to investigate whether ondansetron, a serotonin receptor antagonist could attenuate rotavirus-and norovirus-induced vomiting and diarrhoea, which would facilitate oral rehydration and possibly accelerate recovery and reduce need for hospitalization. Children with acute gastroenteritis, aged 6 months to 16 years where enrolled (n = 104) and randomized to one single oral dose (0.15mg/kg) of ondansetron (n = 52) or placebo (n = 52). The number of diarrhoea and vomiting episodes during the 24 hours following treatment was reported as well as the number of days with symptoms. Pathogens in faeces were diagnosed by real-time PCR. Outcome parameters were analyzed for rotavirus-and noroviruspositive children. One dose of oral ondansetron reduced duration of rotavirus clinical symptoms (p = 0.014), with a median of two days. Furthermore, ondansetron reduced diarrhea episodes, most pronounced in children that had been sick for more than 3 days before treatment (p = 0.028). Ondansetron may be a beneficial treatment for children with rotavirus gastroenteritis.
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Novak, D.Sahlgrens University Hospital, Sweden
(author)
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Ekstrom, M.Sahlgrens University Hospital, Sweden
(author)
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Khalid, Y.Sahlgrens University Hospital, Sweden
(author)
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Andersson, MariaGothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg, Sweden(Swepub:gu)xanman
(author)
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Lindh, Magnus,1960Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,University of Gothenburg, Sweden(Swepub:gu)xlmagr
(author)
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Nordgren, JohanLinköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten(Swepub:liu)johno12
(author)
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Svensson, LennartKarolinska Institutet,Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten,Karolinska Institute, Sweden(Swepub:liu)lensv66
(author)
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Linköpings universitetAvdelningen för mikrobiologi och molekylär medicin
(creator_code:org_t)
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In:PLoS ONE: Public Library of Science (PLoS)12:101932-6203
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