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Results of NOPHO AL...
Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia.
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Toft, N (author)
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Birgens, H (author)
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- Abrahamsson, Jonas, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Griškevičius, L (author)
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- Hallböök, Helene (author)
- Uppsala universitet,Hematologi
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- Heyman, M (author)
- Karolinska Institutet
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Klausen, T W (author)
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Jónsson, Ó G (author)
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Palk, K (author)
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Pruunsild, K (author)
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Quist-Paulsen, P (author)
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Vaitkeviciene, G (author)
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Vettenranta, K (author)
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Åsberg, A (author)
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Frandsen, T L (author)
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Marquart, H V (author)
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Madsen, H O (author)
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- Norén-Nyström, Ulrika (author)
- Umeå universitet,Pediatrik
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Schmiegelow, K (author)
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(creator_code:org_t)
- 2017-08-18
- 2018
- English.
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In: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 32, s. 606-615
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Abstract
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- Adults with acute lymphoblastic leukemia (ALL) do worse than children. From 7/2008 to 12/2014, Nordic and Baltic centers treated 1509 consecutive patients aged 1-45 years with Philadelphia chromosome-negative ALL according to the NOPHO ALL2008 without cranial irradiation. Overall, 1022 patients were of age 1-9 years (A), 266 were 10-17 years (B) and 221 were 18-45 years (C). Sixteen patients (three adults) died during induction. All others achieved remission after induction or 1-3 intensive blocks. Subsequently, 45 patients (12 adults) died, 122 patients relapsed (32 adults) with a median time to relapse of 1.6 years and 13 (no adult) developed a second malignancy. Median follow-up time was 4.6 years. Among the three age groups, older patients more often had higher risk ALL due to T-ALL (32%/25%/9%, P<0.001), KMT2A rearrangements (6%/5%/3%, P<0.001) and higher day 29 residual leukemia for B-lineage (P<0.001), but not T-ALL (P=0.53). Event-free survival rates (pEFS5y) were 89±1% (A), 80±3% (B) and 74±4% (C) with significant differences only for non-high risk groups. Except for thrombosis, pancreatitis and osteonecrosis, the risk of 19 specified toxicities was not enhanced by age above 10 years. In conclusion, a pediatric-based protocol is tolerable and effective for young adults, despite their increased frequency of higher risk features.Leukemia advance online publication, 22 September 2017; doi:10.1038/leu.2017.265.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- ref (subject category)
- art (subject category)
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Leukemia
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- By the author/editor
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Toft, N
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Birgens, H
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Abrahamsson, Jon ...
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Griškevičius, L
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Hallböök, Helene
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Heyman, M
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show more...
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Klausen, T W
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Jónsson, Ó G
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Palk, K
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Pruunsild, K
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Quist-Paulsen, P
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Vaitkeviciene, G
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Vettenranta, K
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Åsberg, A
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Frandsen, T L
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Marquart, H V
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Madsen, H O
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Norén-Nyström, U ...
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Schmiegelow, K
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Leukemia
- By the university
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University of Gothenburg
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Umeå University
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Uppsala University
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Karolinska Institutet