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Neurogranin, a syna...
Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers
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Casaletto, K. B. (author)
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Elahi, F. M. (author)
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Bettcher, B. M. (author)
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Neuhaus, J. (author)
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Bendlin, B. B. (author)
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Asthana, S. (author)
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Johnson, S. C. (author)
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Yaffe, K. (author)
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Carlsson, C. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Kramer, J. H. (author)
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Neurology. - 0028-3878. ; 89:17, s. 1782-1788
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Objective: To determine the association between synaptic functioning as measured via neurogranin in CSF and cognition relative to established Alzheimer disease (AD) biomarkers in neurologically healthy older adults. Methods: We analyzed CSF concentrations of neurogranin, b-amyloid (Ab42), phosphorylated tau (p-tau), and total tau (t-tau) among 132 neurologically normal older adults (mean 64.5, range 55-85), along with bilateral hippocampal volumes and a measure of episodic memory (Auditory Verbal Learning Test, delayed recall). Univariable analyses examined the relationship between neurogranin and the other AD-related biomarkers. Multivariable regression models examined the relationship between neurogranin and delayed recall, adjusting for age and sex, and interaction terms (neurogranin 3 AD biomarkers). Results: Higher neurogranin concentrations were associated with older age (r 5 0.20, p 5 0.02), lower levels of p-tau and t-tau, and smaller hippocampal volumes (p>0.03), but not with CSF Ab42 (p 5 0.18). In addition, CSF neurogranin demonstrated a significant relationship with memory performance independent of the AD-related biomarkers; individuals with the lowest CSF neurogranin concentrations performed better on delayed recall than those with medium or high CSF neurogranin concentrations (p>0.01). Notably, CSF p-tau, t-tau, and Ab42 and hippocampal volumes were not significantly associated with delayed recall scores (p<0.40), and did not interact with neurogranin to predict memory (p<0.10). © 2017 The Author(s).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- amyloid beta protein[1-42]
- neurogranin
- tau protein
- amyloid beta protein
- amyloid beta-protein (1-42)
- apolipoprotein E
- peptide fragment
- adult
- Alzheimer disease
- Article
- Boston naming test
- brain size
- Clinical Dementia Rating
- controlled study
- female
- hippocampus
- human
- major clinical study
- male
- memory
- middle aged
- nuclear magnetic resonance imaging
- priority journal
- protein cerebrospinal fluid level
- protein phosphorylation
- recall
- Rey auditory verbal learning test
- scoring system
- symbol digit modalities test
- task performance
- Wechsler adult intelligence scale
- aged
- cerebrospinal fluid
- complication
- cross-sectional study
- diagnostic imaging
- enzyme linked immunosorbent assay
- genetics
- independent living
- Memory Disorders
- neuropsychological test
- physiology
- statistics and numerical data
- three dimensional imaging
- very elderly
- Aged
- 80 and over
- Amyloid beta-Peptides
- Apolipoproteins E
- Cross-Sectional Studies
- Enzyme-Linked Immunosorbent Assay
- Humans
- Imaging
- Three-Dimensional
- Magnetic Resonance Imaging
- Mental Recall
- Neuropsychological Tests
- Peptide Fragments
- tau Proteins
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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- By the author/editor
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Casaletto, K. B.
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Elahi, F. M.
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Bettcher, B. M.
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Neuhaus, J.
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Bendlin, B. B.
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Asthana, S.
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show more...
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Johnson, S. C.
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Yaffe, K.
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Carlsson, C.
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Kramer, J. H.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurology
- By the university
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University of Gothenburg