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Cutting Edge: Genet...
Cutting Edge: Genetic Association between IFI16 Single Nucleotide Polymorphisms and Resistance to Genital Herpes Correlates with IFI16 Expression Levels and HSV-2-Induced IFN-β Expression.
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- Eriksson, Kristina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Svensson, Alexandra, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Hait, Alon S (author)
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- Schlüter, Kerstin (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Tunbäck, Petra, 1965 (author)
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- Nordström, Inger, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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- Padyukov, Leonid (author)
- Karolinska Institutet
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- Liljeqvist, Jan-Åke, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Mogensen, Trine H (author)
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Paludan, Søren R (author)
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(creator_code:org_t)
- 2017-10-15
- 2017
- English.
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In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 199:8, s. 2613-2617
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Abstract
Subject headings
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- IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor proposed to act in the cyclic GMP-AMP synthase-stimulator of IFN genes pathway. Because mice do not have a clear ortholog of IFI16, this system is not suitable for genetic studies of IFI16. In this study, we have compared the dependency on IFI16, cyclic GMP-AMP synthase, and stimulator of IFN genes for type I IFN induction by a panel of pathogenic bacteria and DNA viruses. The IFN response induced by HSV-2 was particularly dependent on IFI16. In a cohort of patients with genital herpes and healthy controls, the minor G allele of the IFI16 single nucleotide polymorphism rs2276404 was associated with resistance to infection. Furthermore, the combination of this allele with the C allele of rs1417806 was significantly overrepresented in uninfected individuals. Cells from individuals with the protective GC haplotype expressed higher levels of IFI16 and induced more IFN-β upon HSV-2 infection. These data provide genetic evidence for a role for IFI16 in protection against genital herpes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
Keyword
- Adult
- Aged
- Animals
- Cell Line
- Cohort Studies
- DNA
- Viral
- immunology
- Gene Frequency
- Genetic Association Studies
- Genotype
- Herpes Genitalis
- immunology
- Herpesvirus 2
- Human
- immunology
- Humans
- Interferon-beta
- metabolism
- Male
- Mice
- Middle Aged
- Nuclear Proteins
- genetics
- metabolism
- Phosphoproteins
- genetics
- metabolism
- Polymorphism
- Single Nucleotide
- Up-Regulation
- Young Adult
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Eriksson, Kristi ...
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Svensson, Alexan ...
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Hait, Alon S
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Schlüter, Kersti ...
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Tunbäck, Petra, ...
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Nordström, Inger ...
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show more...
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Padyukov, Leonid
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Liljeqvist, Jan- ...
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Mogensen, Trine ...
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Paludan, Søren R
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
- Articles in the publication
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Journal of immun ...
- By the university
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University of Gothenburg
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Karolinska Institutet