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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005275naa a2200817 4500
001oai:gup.ub.gu.se/260615
003SwePub
008240528s2018 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/2606152 URI
0247 a https://doi.org/10.1530/EJE-17-07072 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wijnen, Mark4 aut
2451 0a Excess morbidity and mortality in patients with craniopharyngioma: a hospital-based retrospective cohort study.
264 1c 2018
520 a Most studies in patients with craniopharyngioma did not investigate morbidity and mortality relative to the general population nor evaluated risk factors for excess morbidity and mortality. Therefore, the objective of this study was to examine excess morbidity and mortality, as well as their determinants in patients with craniopharyngioma.Hospital-based retrospective cohort study conducted between 1987 and 2014.We included 144 Dutch and 80 Swedish patients with craniopharyngioma identified by a computer-based search in the medical records (105 females (47%), 112 patients with childhood-onset craniopharyngioma (50%), 3153 person-years of follow-up). Excess morbidity and mortality were analysed using standardized incidence and mortality ratios (SIRs and SMRs). Risk factors were evaluated univariably by comparing SIRs and SMRs between non-overlapping subgroups.Patients with craniopharyngioma experienced excess morbidity due to type 2 diabetes mellitus (T2DM) (SIR: 4.4, 95% confidence interval (CI): 2.8-6.8) and cerebral infarction (SIR: 4.9, 95% CI: 3.1-8.0) compared to the general population. Risks for malignant neoplasms, myocardial infarctions and fractures were not increased. Patients with craniopharyngioma also had excessive total mortality (SMR: 2.7, 95% CI: 2.0-3.8), and mortality due to circulatory (SMR: 2.3, 95% CI: 1.1-4.5) and respiratory (SMR: 6.0, 95% CI: 2.5-14.5) diseases. Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence were identified as risk factors for excess T2DM, cerebral infarction and total mortality.Patients with craniopharyngioma are at an increased risk for T2DM, cerebral infarction, total mortality and mortality due to circulatory and respiratory diseases. Female sex, childhood-onset craniopharyngioma, hydrocephalus and tumour recurrence are important risk factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Adolescent
653 a Adult
653 a Age of Onset
653 a Cerebral Infarction
653 a complications
653 a epidemiology
653 a Child
653 a Cohort Studies
653 a Craniopharyngioma
653 a epidemiology
653 a mortality
653 a Diabetes Mellitus
653 a Type 2
653 a complications
653 a epidemiology
653 a Female
653 a Hospital Mortality
653 a Humans
653 a Hydrocephalus
653 a complications
653 a epidemiology
653 a mortality
653 a Incidence
653 a Male
653 a Middle Aged
653 a Morbidity
653 a Netherlands
653 a epidemiology
653 a Pituitary Neoplasms
653 a epidemiology
653 a mortality
653 a Retrospective Studies
653 a Risk Factors
653 a Sex Factors
653 a Sweden
653 a epidemiology
653 a Young Adult
7001 a Olsson, Daniel S,d 1983u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xolssd
7001 a van den Heuvel-Eibrink, Marry M4 aut
7001 a Hammarstrand, Casper,d 1990u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xhammc
7001 a Janssen, Joseph A M J L4 aut
7001 a van der Lely, Aart J4 aut
7001 a Johannsson, Gudmundur,d 1960u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xjgudn
7001 a Neggers, Sebastian J C M M4 aut
7102 a Göteborgs universitetb Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition4 org
7730 t European journal of endocrinologyg 178:1, s. 95-104q 178:1<95-104x 1479-683X
8564 8u https://gup.ub.gu.se/publication/260615
8564 8u https://doi.org/10.1530/EJE-17-0707

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