The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up.

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Wijnen, Mark (author)

The metabolic syndrome and its components in 178 patients treated for craniopharyngioma after 16 years of follow-up.

Article/chapterEnglish2018

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2018

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LIBRIS-ID:oai:gup.ub.gu.se/260617
https://gup.ub.gu.se/publication/260617URI
https://doi.org/10.1530/EJE-17-0387DOI

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Language:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Patients with craniopharyngioma are at an increased risk for cardio- and cerebrovascular mortality. The metabolic syndrome (MetS) is an important cardiometabolic risk factor, but barely studied in patients with craniopharyngioma. We aimed to investigate the prevalence of and risk factors for the MetS and its components in patients with craniopharyngioma.Cross-sectional study with retrospective data.We studied the prevalence of and risk factors for the MetS and its components in 110 Dutch (median age 47 years, range 18-92) and 68 Swedish (median age 50 years, range 20-81) patients with craniopharyngioma with ≥3 years of follow-up (90 females (51%); 83 patients with childhood-onset craniopharyngioma (47%); median follow-up after craniopharyngioma diagnosis 16 years (range 3-62)). In Dutch patients aged 30-70 years and Swedish patients aged 45-69 years, we examined the prevalence of the MetS and its components relative to the general population.Sixty-nine (46%) of 149 patients with complete data demonstrated the MetS. Prevalence of the MetS was significantly higher in patients with craniopharyngioma compared with the general population (40% vs 26% (P<0.05) for Dutch patients; 52% vs 15% (P<0.05) for Swedish patients). Multivariable logistic regression analysis identified visual impairment as a borderline significant predictor of the MetS (OR 2.54, 95% CI 0.95-6.81; P=0.06) after adjustment for glucocorticoid replacement therapy and follow-up duration. Age, female sex, tumor location, radiological hypothalamic damage, 90Yttrium brachytherapy, glucocorticoid replacement therapy and follow-up duration significantly predicted components of the MetS.Patients with craniopharyngioma are at an increased risk for the MetS, especially patients with visual impairment.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
Adolescent
Adult
Aged
Aged
80 and over
Craniopharyngioma
diagnostic imaging
epidemiology
therapy
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Male
Metabolic Syndrome
diagnostic imaging
epidemiology
therapy
Middle Aged
Retrospective Studies
Risk Factors
Treatment Outcome
Vision Disorders
diagnostic imaging
epidemiology
therapy
Young Adult

Added entries (persons, corporate bodies, meetings, titles ...)

Olsson, Daniel S,1983Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xolssd (author)
van den Heuvel-Eibrink, Marry M (author)
Hammarstrand, Casper,1990Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xhammc (author)
Janssen, Joseph A M J L (author)
van der Lely, Aart-Jan (author)
Johannsson, Gudmundur,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xjgudn (author)
Neggers, Sebastian J C M M (author)
Göteborgs universitetInstitutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (creator_code:org_t)

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In:European journal of endocrinology178:1, s. 11-221479-683X

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