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Transcriptional sig...
Transcriptional signature of human pro-inflammatory T(H)17 cells identifies reduced IL10 gene expression in multiple sclerosis
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Hu, D. (author)
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Notarbartolo, S. (author)
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Croonenborghs, T. (author)
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Patel, B. (author)
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Cialic, R. (author)
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Yang, T. H. (author)
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Aschenbrenner, D. (author)
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- Andersson, Karin, 1972 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Gattorno, M. (author)
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Pham, M. (author)
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Kivisakk, P. (author)
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Pierre, I. V. (author)
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Lee, Y. (author)
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Kiani, K. (author)
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- Bokarewa, Maria, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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Tjon, E. (author)
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Pochet, N. (author)
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Sallusto, F. (author)
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Kuchroo, V. K. (author)
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Weiner, H. L. (author)
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(creator_code:org_t)
- 2017-11-17
- 2017
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- We have previously reported the molecular signature of murine pathogenic T(H)17 cells that induce experimental autoimmune encephalomyelitis (EAE) in animals. Here we show that human peripheral blood IFN-gamma(+) IL-17(+) (T(H)1/17) and IFN-gamma(-)-IL-17(+) (T(H)17) CD4(+) T cells display distinct transcriptional profiles in high-throughput transcription analyses. Compared to T(H)17 cells, T(H)1/17 cells have gene signatures with marked similarity to mouse pathogenic T(H)17 cells. Assessing 15 representative signature genes in patients with multiple sclerosis, we find that T(H)1/17 cells have elevated expression of CXCR3 and reduced expression of IFNG, CCL3, CLL4, GZMB, and IL10 compared to healthy controls. Moreover, higher expression of IL10 in T(H)17 cells is found in clinically stable vs. active patients. Our results define the molecular signature of human pro-inflammatory T(H)17 cells, which can be used to both identify pathogenic T(H)17 cells and to measure the effect of treatment on T(H)17 cells in human autoimmune diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- experimental autoimmune encephalomyelitis
- set enrichment analysis
- central-nervous-system
- hyper-ige syndrome
- th17 cells
- ifn-gamma
- t-cells
- disease
- bet
- induction
- Science & Technology - Other Topics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hu, D.
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Notarbartolo, S.
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Croonenborghs, T ...
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Patel, B.
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Cialic, R.
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Yang, T. H.
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show more...
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Aschenbrenner, D ...
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Andersson, Karin ...
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Gattorno, M.
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Pham, M.
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Kivisakk, P.
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Pierre, I. V.
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Lee, Y.
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Kiani, K.
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Bokarewa, Maria, ...
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Tjon, E.
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Pochet, N.
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Sallusto, F.
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Kuchroo, V. K.
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Weiner, H. L.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Nature Communica ...
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University of Gothenburg