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  • Willems, S. M.University of Cambridge,King's College London,Guy's and St Thomas' NHS Foundation Trust,University of Cagliari (author)

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-07-12
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/261109
  • https://gup.ub.gu.se/publication/261109URI
  • https://doi.org/10.1038/ncomms16015DOI
  • https://lup.lub.lu.se/record/d51024e0-6b80-4e15-a890-7e4e996f6d3fURI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-137942URI

Supplementary language notes

  • Language:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-scale genetic discovery analysis in a combined sample of 195,180 individuals and identify 16 loci associated with grip strength (P<5 × 10-8) in combined analyses. A number of these loci contain genes implicated in structure and function of skeletal muscle fibres (ACTG1), neuronal maintenance and signal transduction (PEX14, TGFA, SYT1), or monogenic syndromes with involvement of psychomotor impairment (PEX14, LRPPRC and KANSL1). Mendelian randomization analyses are consistent with a causal effect of higher genetically predicted grip strength on lower fracture risk. In conclusion, our findings provide new biological insight into the mechanistic underpinnings of grip strength and the causal role of muscular strength in age-related morbidities and mortality. © The Author(s) 2017.

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  • Wright, D. J.University of Cambridge (author)
  • Day, F. R.University of Cambridge (author)
  • Trajanoska, K.Erasmus University Medical Center (author)
  • Joshi, P. K.University of Edinburgh (author)
  • Morris, J. A.McGill University (author)
  • Matteini, A. M.Johns Hopkins University School of Medicine,Glostrup Hospital (author)
  • Garton, F. C.University of Queensland (author)
  • Grarup, N.University of Copenhagen (author)
  • Oskolkov, NikolaySkåne University Hospital(Swepub:lu)fkem-nyo (author)
  • Thalamuthu, A.University of New South Wales (author)
  • Lindgren, Cecilia M.University of Oxford,Broad Institute(Swepub:lu)endo-cli (author)
  • Liu, J.Erasmus University Medical Center (author)
  • Demirkan, A.Erasmus University Medical Center,Leiden University Medical Centre (author)
  • Lek, M.Massachusetts General Hospital,Harvard Medical School (author)
  • Xu, L.Harvard Medical School,Massachusetts General Hospital (author)
  • Wang, G.University of Brighton (author)
  • Oldmeadow, C.Hunter Medical Research Institute, Australia (author)
  • Gaulton, K. J.University of California, San Diego (author)
  • Lotta, L. A.University of Cambridge,Glostrup Hospital,Copenhagen University Hospital,University of Copenhagen,12 de Octubre University Hospital (author)
  • Miyamoto-Mikami, E.Japan Society for the Promotion of Science (author)
  • Rivas, M. A.Stanford University,Broad Institute (author)
  • White, T.University of Cambridge (author)
  • Loh, P. R.Harvard University,Broad Institute (author)
  • Aadahl, M. (author)
  • Amin, N.Erasmus University Medical Center (author)
  • Attia, J. R.Hunter Medical Research Institute, Australia (author)
  • Austin, K.University of Brighton (author)
  • Benyamin, B.University of Queensland (author)
  • Brage, S.University of Cambridge (author)
  • Cheng, Y. C.Slotervaart Hospital (author)
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  • Papadimitriou, I.Victoria University (author)
  • Rajpal, D. K.SmithKline Beecham Pharmaceuticals (author)
  • Sale, C.Nottingham Trent University (author)
  • Schnurr, T. M. (author)
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  • Tobin, M. D. (author)
  • Varley, I. (author)
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  • Pitsiladis, Y. (author)
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  • Franks, Paul W.Umeå universitet,Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Genetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Skånes University Hospital, 222 41 Lund, Sweden,Medicin,Enheten för biobanksforskning(Swepub:umu)pafr0003 (author)
  • North, K. N. (author)
  • Van Duijn, C. M. (author)
  • Mather, K. A. (author)
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  • Hansson, OlaSkåne University Hospital(Swepub:lu)medk-oha (author)
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  • Langenberg, C. (author)
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  • Wareham, N. J. (author)
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  • Zheng, H. F. (author)
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  • Leong, A. (author)
  • Ahmad, O. S. (author)
  • Laurin, C. (author)
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  • Ross, S. (author)
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  • Warrington, N. M. (author)
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  • Ingvarsson, ThorvaldurAkureyri Central Hospital,University of Akureyri(Swepub:lu)extLU-875 (author)
  • Kähönen, M. (author)
  • Kammerer, C. (author)
  • Lacroix, A. Z. (author)
  • Li, G. (author)
  • Liu, C. T. (author)
  • Liu, Y. (author)
  • Lorentzon, Mattias,1970Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xlomat (author)
  • Papadimitriou, Loannis (author)
  • University of CambridgeKing's College London (creator_code:org_t)

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  • In:Nature Communications: Springer Science and Business Media LLC82041-1723

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By the author/editor
Willems, S. M.
Wright, D. J.
Day, F. R.
Trajanoska, K.
Joshi, P. K.
Morris, J. A.
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Xu, L.
Wang, G.
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Rivas, M. A.
White, T.
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Amin, N.
Attia, J. R.
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Lucia, A.
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Sale, C.
Schnurr, T. M.
Sessa, F.
Shrine, N.
Tobin, M. D.
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Wain, L. V.
Wray, N. R.
Lindgren, C. M.
MacArthur, D. G.
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McCarthy, M. I.
Pedersen, O.
Khaw, K. T.
Kiel, D. P.
Pitsiladis, Y.
Fuku, N.
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Van Duijn, C. M.
Mather, K. A.
Hansen, T.
Hansson, Ola
Spector, T.
Murabito, J. M.
Richards, J. B.
Rivadeneira, F.
Langenberg, C.
Perry, J. R. B.
Wareham, N. J.
Scott, R. A.
Oei, L.
Zheng, H. F.
Forgetta, V.
Leong, A.
Ahmad, O. S.
Laurin, C.
Mokry, L. E.
Ross, S.
Elks, C. E.
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Murray, A.
Ruth, K. S.
Tsilidis, K. K.
Medina-Gómez, C.
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Bis, J. C.
Chasman, D. I.
Demissie, S.
Enneman, A. W.
Hsu, Y. H.
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Kammerer, C.
Lacroix, A. Z.
Li, G.
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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MEDICAL AND HEALTH SCIENCES
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and Physiology
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NATURAL SCIENCES
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By the university
University of Gothenburg
Lund University
Umeå University

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